Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India

Aparajita Samaddar; Manas Talukdar; Santasmita Pal; Ipsita Saha; Anadi Roy Chowdhury

doi:10.5455/njppp.2022.12.03124202221032022

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Natl J Physiol Pharm Pharmacol. 2022; 12(5): 639-642

doi: 10.5455/njppp.2022.12.03124202221032022

Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India

Aparajita Samaddar, Manas Talukdar, Santasmita Pal, Ipsita Saha, Anadi Roy Chowdhury.

Abstract
Background: Although most of the COVID-19 patients presented with mild symptoms and recovered, a considerable number of cases became serious with poor prognosis in an unpredictable manner. They mostly presented with respiratory symptoms and coagulation abnormalities with thrombosis and multi-organ failure. Hence, timely prediction of these cases with the early intervention might decrease mortality.

Aims and Objectives: The objectives of this were to determine whether values of fibrinogen, fibrin degradation products (FDP), and D-dimer level correlates with disease severity in COVID-19 patients.

Materials and Methods: This observational cross-sectional study was done on total 400 hospitalized COVID-19 adult patients where patients were categorized into moderate and severe cases as per guideline of Government of India. Patients with pre-existing coagulation disorder or receiving anticoagulant drugs were excluded from the study. FDP, fibrinogen, and D-dimer values of these two groups were evaluated and compared statistically to determine their significance.

Results: Overall mean and standard deviation of fibrinogen, FDP, and D-dimer were 607.48 ± 177.73, 34.93 ± 29.2, and 6.23 ± 6.48 for severe category, while for moderate category disease, they were 389.77 ± 110.16, 10.79 ± 10.47, and 1.96 ± 3.3, respectively. Unpaired t-test showed that the study parameters are significantly higher in severe COVID-19 patients compared to moderate ones.

Conclusion: It was concluded that elevated level of D-dimer, fibrinogen, and FDP is indicator of disease progression in COVID-19. Thus, regular estimation of these simple coagulation parameters may predict disease severity and help in adequate management.

Key words: COVID-19; Fibrinogen; Fibrin Fibrinogen degradation products; D-dimer; Severity

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Pubmed Style

Samaddar A, Talukdar M, Pal S, Saha I, Chowdhury AR. Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 639-642. doi:10.5455/njppp.2022.12.03124202221032022

Web Style

Samaddar A, Talukdar M, Pal S, Saha I, Chowdhury AR. Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. https://www.njppp.com/?mno=103402 [Access: June 03, 2023]. doi:10.5455/njppp.2022.12.03124202221032022

AMA (American Medical Association) Style

Samaddar A, Talukdar M, Pal S, Saha I, Chowdhury AR. Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 639-642. doi:10.5455/njppp.2022.12.03124202221032022

Vancouver/ICMJE Style

Samaddar A, Talukdar M, Pal S, Saha I, Chowdhury AR. Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol. (2022), [cited June 03, 2023]; 12(5): 639-642. doi:10.5455/njppp.2022.12.03124202221032022

Harvard Style

Samaddar, A., Talukdar, . M., Pal, . S., Saha, . I. & Chowdhury, . A. R. (2022) Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol, 12 (5), 639-642. doi:10.5455/njppp.2022.12.03124202221032022

Turabian Style

Samaddar, Aparajita, Manas Talukdar, Santasmita Pal, Ipsita Saha, and Anadi Roy Chowdhury. 2022. Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 639-642. doi:10.5455/njppp.2022.12.03124202221032022

Chicago Style

Samaddar, Aparajita, Manas Talukdar, Santasmita Pal, Ipsita Saha, and Anadi Roy Chowdhury. "Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 639-642. doi:10.5455/njppp.2022.12.03124202221032022

MLA (The Modern Language Association) Style

Samaddar, Aparajita, Manas Talukdar, Santasmita Pal, Ipsita Saha, and Anadi Roy Chowdhury. "Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India." National Journal of Physiology, Pharmacy and Pharmacology 12.5 (2022), 639-642. Print. doi:10.5455/njppp.2022.12.03124202221032022

APA (American Psychological Association) Style

Samaddar, A., Talukdar, . M., Pal, . S., Saha, . I. & Chowdhury, . A. R. (2022) Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients – A cross-sectional study in Eastern India. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 639-642. doi:10.5455/njppp.2022.12.03124202221032022

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