Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers

Pavithra Vyshnavi Yogisparan; Rashmi Ramanathan; Mohan Jayabal; Vinothkumar Selvaraj; Jeevithan Shanmugam

doi:10.5455/njppp.2022.12.07258202106082021

2024, Vol: 14, Issue: 10

14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form

« Previous Article

Original Research
Online Published: 27 Aug 2021

Natl J Physiol Pharm Pharmacol. 2022; 12(1): 74-78

doi: 10.5455/njppp.2022.12.07258202106082021

Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers

Pavithra Vyshnavi Yogisparan, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, Jeevithan Shanmugam.

Abstract
Background: Gastrointestinal (GI) autonomic neuropathy and reflux esophagitis are common in chronic diabetics. To gauge the adequacy of peristalsis, high-resolution esophageal manometry is considered as a reliable test.

Aim and Objective: To compare the GI symptoms and high-resolution manometry parameters between type II diabetes patients and normal volunteers.

Materials and Methods: This comparative study was conducted on 35 known type II diabetes mellitus patients (hemoglobin A1c [HbA1c] levels ≥6.5%) and 35 normal volunteers between the age group of 35 and 70 years. Sociodemographic details, drug history, disease duration, and GI symptoms were elicited among the study participants. HbA1c and High-resolution manometry were measured for all the participants.

Results: The frequency of epigastric pain (31.48%), heartburn (34.28%), pharyngeal irritation (31.43%), and loose stools (37.14%) were significantly higher in the diabetics. Significant difference (P < 0.05) was observed in mean basal expiratory pressure (MBEP) and mean basal inspiratory pressure (MBIP) values between diabetics and controls. There was a positive significant correlation between esophagogastric junction contractile integral and MBIP (r = 0.557), MBEP (r = 0.583), Median Integrated Relaxation pressure (r = 0.410).

Conclusion: Hyperglycaemia seems to be an independent risk factor for gastroesophageal reflux disease (GERD). Obesity significantly increments the occurrence of GERD in diabetics. Strict adherence to preventive measures such as weight reduction, diet management, glycaemic control will have a great impact on the occurrence of GERD in diabetics.

Key words: High-resolution Manometry; Hemoglobin A1c; Type 2 Diabetes Mellitus; Gastrointestinal Symptoms

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Pavithra Vyshnavi Yogisparan Articles by Rashmi Ramanathan Articles by Mohan Jayabal Articles by Vinothkumar Selvaraj Articles by Jeevithan Shanmugam
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. Natl J Physiol Pharm Pharmacol. 2022; 12(1): 74-78. doi:10.5455/njppp.2022.12.07258202106082021

Web Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. https://www.njppp.com/?mno=99226 [Access: November 02, 2024]. doi:10.5455/njppp.2022.12.07258202106082021

AMA (American Medical Association) Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. Natl J Physiol Pharm Pharmacol. 2022; 12(1): 74-78. doi:10.5455/njppp.2022.12.07258202106082021

Vancouver/ICMJE Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. Natl J Physiol Pharm Pharmacol. (2022), [cited November 02, 2024]; 12(1): 74-78. doi:10.5455/njppp.2022.12.07258202106082021

Harvard Style

Yogisparan, P. V., Ramanathan, . R., Jayabal, . M., Selvaraj, . V. & Shanmugam, . J. (2022) Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. Natl J Physiol Pharm Pharmacol, 12 (1), 74-78. doi:10.5455/njppp.2022.12.07258202106082021

Turabian Style

Yogisparan, Pavithra Vyshnavi, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, and Jeevithan Shanmugam. 2022. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. National Journal of Physiology, Pharmacy and Pharmacology, 12 (1), 74-78. doi:10.5455/njppp.2022.12.07258202106082021

Chicago Style

Yogisparan, Pavithra Vyshnavi, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, and Jeevithan Shanmugam. "Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 74-78. doi:10.5455/njppp.2022.12.07258202106082021

MLA (The Modern Language Association) Style

Yogisparan, Pavithra Vyshnavi, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, and Jeevithan Shanmugam. "Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers." National Journal of Physiology, Pharmacy and Pharmacology 12.1 (2022), 74-78. Print. doi:10.5455/njppp.2022.12.07258202106082021

APA (American Psychological Association) Style

Yogisparan, P. V., Ramanathan, . R., Jayabal, . M., Selvaraj, . V. & Shanmugam, . J. (2022) Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. National Journal of Physiology, Pharmacy and Pharmacology, 12 (1), 74-78. doi:10.5455/njppp.2022.12.07258202106082021

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Digital Archiving & Preservation Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article