E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models

Atanu Roy, Ravindran Revand, Sanjeev K Singh.

Abstract
Background: Peripheral blood vessels are concerned with sensing the perivascular nociceptive information and signaling it to the higher centers through ipsilateral somatic nerves, thereby regulating the cardiorespiratory parameters by means of vasosensory reflex responses.

Aims and Objectives: The present study was conducted to compare the potency of nociceptive responses elicited by bradykinin (BK) with the capsaicin-induced responses.

Materials and Methods: Charles-Foster rats were anesthetized with urethane and injected intraperitoneally. After tracheostomy, the right femoral artery was cannulated with a 24G, double ported cannula for administering the chemicals/saline through vertical port and to record the blood pressure (BP) through horizontal port. BP, Electrocardiogram, and respiratory movements were recorded.

Results: Injection of capsaicin into a segment of femoral artery evoked instantaneous transient tachypnoeic, hyperventilatory, and hypotensive responses. BK also produced similar pattern of nociceptive responses along with a transient fall in heart rate. In addition, the vasosensory responses produced by BK are of greater magnitude as compared to the capsaicin.

Conclusions: BK is more potent in eliciting reflex nociceptive responses as compared to capsaicin. Further, BK has an additional cardioprotective role by slowing the heart, in the events of acute inflammation.

Key words: Capsaicin; Bradykinin; Nociception; Vasosensory Reflexes; Cardiorespiratory Changes


 
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Pubmed Style

Roy A, Revand R, Singh SK. Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022


Web Style

Roy A, Revand R, Singh SK. Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. https://www.njppp.com/?mno=50395 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.05247202203062022


AMA (American Medical Association) Style

Roy A, Revand R, Singh SK. Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022



Vancouver/ICMJE Style

Roy A, Revand R, Singh SK. Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(7): 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022



Harvard Style

Roy, A., Revand, . R. & Singh, . S. K. (2022) Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. Natl J Physiol Pharm Pharmacol, 12 (7), 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022



Turabian Style

Roy, Atanu, Ravindran Revand, and Sanjeev K Singh. 2022. Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022



Chicago Style

Roy, Atanu, Ravindran Revand, and Sanjeev K Singh. "Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022



MLA (The Modern Language Association) Style

Roy, Atanu, Ravindran Revand, and Sanjeev K Singh. "Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 1073-1078. Print. doi:10.5455/njppp.2022.12.05247202203062022



APA (American Psychological Association) Style

Roy, A., Revand, . R. & Singh, . S. K. (2022) Bradykinin-induced nociceptive responses are more potent than capsaicin-induced responses in rat models. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1073-1078. doi:10.5455/njppp.2022.12.05247202203062022