E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital

Jayant Rai, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, Preeti Yadav.

Abstract
Background: Epilepsy is one of the common neurological disorders diagnosed early in life. Availability of many antiepileptic drugs (AEDs) makes it difficult to choose the appropriate pharmacotherapy.

Aim and Objective: Understanding the pattern of AED prescription to evaluate the rationality of AED prescriptions in epileptic patients.

Materials and Methods: This was a retrospective, observational study carried out at new civil hospital, Surat for a duration of 6 months. The study involved collecting data from the case files of all the patients irrespective of age or gender diagnosed with epilepsy and undergoing treatment from any of the outpatient departments of the hospital. Demographic details, clinical diagnosis, and detailed data about the prescribed pharmacotherapy were recorded in a pre-approved data sheet. The WHO prescribing indicators were evaluated for each prescription. Descriptive statistics was used.

Results: The average age of the patients was 21.64 ± 10.46 years. A total of 1565 drugs were prescribed in the 331 epilepsy patients’ prescriptions. Out of this, 551 drugs (35.21%) were antiepileptics. Most of the patients received monotherapy (75.53%). The most commonly prescribed drug was sodium valproate (46.10%) followed by phenytoin (30.13%) and carbamazepine (10%). The average AED per prescription was 1.70. Majority of the prescriptions (94.63%) used generic names. There were no injectable used and no fixed dose combinations were prescribed in any of the patients.

Conclusion: The prescriptions followed the rational prescribing pattern. Treatment of epilepsy is usually by monotherapy with valproate being the most commonly used AED. Prospective studies to evaluate adverse effects and patient compliance will help in efficient policy-making decisions.

Key words: Drug Utilization Study; Prescribing Indicators; Rational Use of Drugs


 
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How to Cite this Article
Pubmed Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 17-20. doi:10.5455/njppp.2023.13.05215202217052022


Web Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. https://www.njppp.com/?mno=34147 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.05215202217052022


AMA (American Medical Association) Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 17-20. doi:10.5455/njppp.2023.13.05215202217052022



Vancouver/ICMJE Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 17-20. doi:10.5455/njppp.2023.13.05215202217052022



Harvard Style

Rai, J., Kaushik, . S., Agrawal, . H., Mahajan, . A. & Yadav, . P. (2023) Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 13 (1), 17-20. doi:10.5455/njppp.2023.13.05215202217052022



Turabian Style

Rai, Jayant, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, and Preeti Yadav. 2023. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 17-20. doi:10.5455/njppp.2023.13.05215202217052022



Chicago Style

Rai, Jayant, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, and Preeti Yadav. "Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 17-20. doi:10.5455/njppp.2023.13.05215202217052022



MLA (The Modern Language Association) Style

Rai, Jayant, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, and Preeti Yadav. "Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 17-20. Print. doi:10.5455/njppp.2023.13.05215202217052022



APA (American Psychological Association) Style

Rai, J., Kaushik, . S., Agrawal, . H., Mahajan, . A. & Yadav, . P. (2023) Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 17-20. doi:10.5455/njppp.2023.13.05215202217052022