Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures

Megaravalli R Manasa; Idoor D Sachin

doi:10.5455/njppp.2016.6.0211201595

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Original Research
Online Published: 27 Feb 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(2): 128-131

doi: 10.5455/njppp.2016.6.0211201595

Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures

Megaravalli R Manasa, Idoor D Sachin.

Cited By:9

Abstract
Background: Antiepileptics available currently cause teratogenicity and chronic toxicity. Several plant extracts exhibit the potential to be developed into newer antiepileptics.

Aims and Objective: To evaluate the anticonvulsant action of aqueous extract of Centella asiatica and compare it with sodium valproate in pentylenetetrazole (PTZ)-induced seizures in albino mice.

Materials and Methods: Twenty-four male albino mice weighing 1830 g were divided into four groups. Group I was administered distilled water, group II sodium valproate (300 mg/kg i.p.), and groups III and IV aqueous extract of C. asiatica (100 mg/kg and 300 mg/kg), respectively. Seizures were induced by giving PTZ (80 mg/kg s.c.) 1 h after administration of the respective treatments. Suppression of clonic seizure was considered as an indicator of anticonvulsant action of the compound.

Result: The aqueous extract of C. asiatica at both doses (100 mg/kg and 300 mg/kg) suppressed the clonic seizures in mice, and this was statistically significant. The anticonvulsant action of the extract at a dose of 300 mg/kg was comparable to that of sodium valproate in this study.

Conclusion: The aqueous extract of C. asiatica at a dose of 300 mg/kg has shown anticonvulsant action comparable to sodium valproate in PTZ-induced seizures.

Key words: Centella asiatica; Pentylenetetrazole, Sodium Valproate

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Pubmed Style

Manasa MR, Sachin ID. Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 128-131. doi:10.5455/njppp.2016.6.0211201595

Web Style

Manasa MR, Sachin ID. Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. https://www.njppp.com/?mno=207803 [Access: November 01, 2025]. doi:10.5455/njppp.2016.6.0211201595

AMA (American Medical Association) Style

Manasa MR, Sachin ID. Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 128-131. doi:10.5455/njppp.2016.6.0211201595

Vancouver/ICMJE Style

Manasa MR, Sachin ID. Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. Natl J Physiol Pharm Pharmacol. (2016), [cited November 01, 2025]; 6(2): 128-131. doi:10.5455/njppp.2016.6.0211201595

Harvard Style

Manasa, M. R. & Sachin, . I. D. (2016) Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. Natl J Physiol Pharm Pharmacol, 6 (2), 128-131. doi:10.5455/njppp.2016.6.0211201595

Turabian Style

Manasa, Megaravalli R, and Idoor D Sachin. 2016. Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 128-131. doi:10.5455/njppp.2016.6.0211201595

Chicago Style

Manasa, Megaravalli R, and Idoor D Sachin. "Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 128-131. doi:10.5455/njppp.2016.6.0211201595

MLA (The Modern Language Association) Style

Manasa, Megaravalli R, and Idoor D Sachin. "Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures." National Journal of Physiology, Pharmacy and Pharmacology 6.2 (2016), 128-131. Print. doi:10.5455/njppp.2016.6.0211201595

APA (American Psychological Association) Style

Manasa, M. R. & Sachin, . I. D. (2016) Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproateA comparative study in pentylenetetrazole-induced seizures. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 128-131. doi:10.5455/njppp.2016.6.0211201595

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