Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model

Pratik Kumar Chatterjee; Vinodini Nithyanandamadom Anantharaya; Anish Singhal; Poulomi Chatterjee; Rashmi Kapu Shiva; Roopashree Mallya

doi:10.5455/njppp.2016.6.2709201591

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Online Published: 27 Feb 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(2): 119-122

doi: 10.5455/njppp.2016.6.2709201591

Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya.

Cited By:9

Abstract
Background: Cadmium (Cd), an environmental metallic toxicant with varying degrees of toxicity, exists in different oxidational or transitional states and causes various blood disorders. Cadmium (Cd) is known to affect various organs on both acute and chronic exposures. Studies have revealed that the most important tissue in body in which metabolic alterations are mainly reproduced is the blood. Moringa oleifera, originally from India, has been scientifically assessed for various medicinal applications.

Aims and Objective: To examine the effect of M. oleifera aqueous extract taken from the leaf on total leukocyte count including its differentials (neutrophils and lymphocytes) in cadmium-treated rats.

Materials and Methods: Twenty-four adult Wistar Albino rats, weighing between 180 and 200 g were broadly divided into four groups, six animals in each group, with group I being the control. Group IV was pretreated with the extract and then cadmium chloride orally for 1 day. Data were presented as mean ± SD and p ≤ 0.05 considered significant.

Result: The results portrayed that pretreatment with Moringa leaf extract, 100 mg/kg/bw, earlier to the cadmium administration exhibited a significant increase (p ≤ 0.001) in the total leukocyte count including its differentials in comparison with the cadmium-exposed group, whereas the total WBC count was significantly decreased in group III in comparison with groups I and II. This study depicts a marked increase in the total leukocyte (T-WBC) count and its differentials in the animals pretreated with Moringa oleifera leaf extract, before the infusion of cadmium could be an indication that M. oleifera offers protection against damage to hematological parameters induced by cadmium.

Conclusion: Therefore, our study suggests that aqueous leaf extract of M. oleifera enhances the immune mechanisms to fight back foreign substances when exposed to cadmium toxicity.

Key words: Cadmium; Blood Disorders; Moringa oleifera; Leukocyte Count; Immune Mechanisms

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Pubmed Style

Chatterjee PK, Anantharaya VN, Singhal A, Chatterjee P, Shiva RK, Mallya R. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 119-122. doi:10.5455/njppp.2016.6.2709201591

Web Style

Chatterjee PK, Anantharaya VN, Singhal A, Chatterjee P, Shiva RK, Mallya R. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. https://www.njppp.com/?mno=202157 [Access: November 01, 2025]. doi:10.5455/njppp.2016.6.2709201591

AMA (American Medical Association) Style

Chatterjee PK, Anantharaya VN, Singhal A, Chatterjee P, Shiva RK, Mallya R. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 119-122. doi:10.5455/njppp.2016.6.2709201591

Vancouver/ICMJE Style

Chatterjee PK, Anantharaya VN, Singhal A, Chatterjee P, Shiva RK, Mallya R. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol. (2016), [cited November 01, 2025]; 6(2): 119-122. doi:10.5455/njppp.2016.6.2709201591

Harvard Style

Chatterjee, P. K., Anantharaya, . V. N., Singhal, . A., Chatterjee, . P., Shiva, . R. K. & Mallya, . R. (2016) Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol, 6 (2), 119-122. doi:10.5455/njppp.2016.6.2709201591

Turabian Style

Chatterjee, Pratik Kumar, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, and Roopashree Mallya. 2016. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 119-122. doi:10.5455/njppp.2016.6.2709201591

Chicago Style

Chatterjee, Pratik Kumar, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, and Roopashree Mallya. "Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 119-122. doi:10.5455/njppp.2016.6.2709201591

MLA (The Modern Language Association) Style

Chatterjee, Pratik Kumar, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, and Roopashree Mallya. "Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model." National Journal of Physiology, Pharmacy and Pharmacology 6.2 (2016), 119-122. Print. doi:10.5455/njppp.2016.6.2709201591

APA (American Psychological Association) Style

Chatterjee, P. K., Anantharaya, . V. N., Singhal, . A., Chatterjee, . P., Shiva, . R. K. & Mallya, . R. (2016) Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 119-122. doi:10.5455/njppp.2016.6.2709201591

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