Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy

Ishu Kansal; Vishal Goel; Mohita Singh

doi:10.5455/njppp.2024.14.11536202308022024

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Original Research
Online Published: 23 Feb 2024

Natl J Physiol Pharm Pharmacol. 2024; 14(4): 795-799

doi: 10.5455/njppp.2024.14.11536202308022024

Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy

Ishu Kansal, Vishal Goel, Mohita Singh.

Abstract
Background: Lack of vitamin D and estrogen both promote a spike in cytokine production, which increases osteoclastogenesis and causes bone resorption. Treatment with vitamin D strongly stimulates calcium resorption and decreases bone turnover. Vitamin D also decreases interleukin-6 (IL-6) levels, which further decreases the activity of osteoclast, which helps in regaining bone mineral density (BMD).

Aims and Objectives: To assess and evaluate the link between serum vitamin D levels, BMD, and IL-6 levels in osteoporotic pre- and post-menopausal women.

Materials and Methods: Three categories are formed among 36 female patients within the age group 30–55 years with osteoporosis: Group-1: Patients within age group 30–40 years; Group-2: Pre-menopausal patients within age group 40–55 years; and Group-3: Postmenopausal patients within age group 40–55 years. Serum 25-hydroxy vitamin D levels, IL-6 levels, and BMD scans were also done at baseline (day 0) before vitamin D supplementation and after 6 months of oral vitamin D therapy.

Results: The comparison between mean values of IL-6, serum 25-hydroxy vitamin D level, and BMD at baseline and at 24th week was highly significant for all three groups, which showed that the post-menopausal group, i.e., Group-3, had the lowest vitamin D levels and the lowest bone mass as compared to the pre-menopausal groups, i.e., Group-2 and Group-1. It was observed that mean values of 25-hydroxy vitamin D and BMD at the 24th week significantly increased and IL-6 values significantly decreased in all the women after 24 weeks of Vitamin D therapy.

Conclusion: There is a straight link between vitamin D and BMD in post-menopausal women and an opposite correlation between vitamin D and IL-6.

Key words: 25-Hydroxy Vitamin D; Interleukin-6; Bone Mineral Density; Osteoporosis

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How to Cite this Article

Pubmed Style

Kansal I, Goel V, Singh M. Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. Natl J Physiol Pharm Pharmacol. 2024; 14(4): 795-799. doi:10.5455/njppp.2024.14.11536202308022024

Web Style

Kansal I, Goel V, Singh M. Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. https://www.njppp.com/?mno=177463 [Access: January 17, 2025]. doi:10.5455/njppp.2024.14.11536202308022024

AMA (American Medical Association) Style

Kansal I, Goel V, Singh M. Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. Natl J Physiol Pharm Pharmacol. 2024; 14(4): 795-799. doi:10.5455/njppp.2024.14.11536202308022024

Vancouver/ICMJE Style

Kansal I, Goel V, Singh M. Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. Natl J Physiol Pharm Pharmacol. (2024), [cited January 17, 2025]; 14(4): 795-799. doi:10.5455/njppp.2024.14.11536202308022024

Harvard Style

Kansal, I., Goel, . V. & Singh, . M. (2024) Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. Natl J Physiol Pharm Pharmacol, 14 (4), 795-799. doi:10.5455/njppp.2024.14.11536202308022024

Turabian Style

Kansal, Ishu, Vishal Goel, and Mohita Singh. 2024. Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. National Journal of Physiology, Pharmacy and Pharmacology, 14 (4), 795-799. doi:10.5455/njppp.2024.14.11536202308022024

Chicago Style

Kansal, Ishu, Vishal Goel, and Mohita Singh. "Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 795-799. doi:10.5455/njppp.2024.14.11536202308022024

MLA (The Modern Language Association) Style

Kansal, Ishu, Vishal Goel, and Mohita Singh. "Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy." National Journal of Physiology, Pharmacy and Pharmacology 14.4 (2024), 795-799. Print. doi:10.5455/njppp.2024.14.11536202308022024

APA (American Psychological Association) Style

Kansal, I., Goel, . V. & Singh, . M. (2024) Association of serum vitamin D, IL-6 levels, and bone mineral density in pre- and post-menopausal women suffering from osteoporosis before and after vitamin D3 supplementation therapy. National Journal of Physiology, Pharmacy and Pharmacology, 14 (4), 795-799. doi:10.5455/njppp.2024.14.11536202308022024

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