Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews

Abdulmajeed Yunusa; Aminu Chika; Shaibu Oricha Bello; Aisha Bello Yahaya; Abubakar Sadiq

doi:10.5455/njppp.2022.12.01044202203032022

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Online Published: 14 Mar 2022

Natl J Physiol Pharm Pharmacol. 2022; 12(4): 395-403

doi: 10.5455/njppp.2022.12.01044202203032022

Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews

Abdulmajeed Yunusa, Aminu Chika, Shaibu Oricha Bello, Aisha Bello Yahaya, Abubakar Sadiq.

Abstract
Background: Benign prostatic hyperplasia (BPH) is defined as a progressive nonmalignant enlargement of smooth muscle and epithelial cells in the prostate. A lot of studies have been published on the efficacy and safety of phytotherapeutic agents against BPH, making it a daunting task to review comprehensively.

Aim and Objectives: The present article aimed to review the existing systematic reviews of primary studies on the subject. Google Scholar and PubMed databases were used in searching the articles.

Materials and Methods: After permission from the departmental ethics committee, the quality of the retrieved articles was assessed using a revised assessment of multiple systematic reviews scale.

Results: Sixteen reviews were included, with the majority (11 out of 16) focusing on Serenoa repens extracts. Such evidence for other phytotherapeutic agents studied is either limited, conflicting, or lacking. Issues about the primary studies included in the reviews were discussed and some recommendations presented.

Conclusion: The reviews that focused on the most widely studied hexanic extract of S. repens, Permixon, were consistent in their conclusions that the extract is beneficial in improving the symptoms of BPH.

Key words: Benign Prostatic Hyperplasia; Clinical Effectiveness; Tolerability; Systematic Reviews

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How to Cite this Article

Pubmed Style

Yunusa A, Chika A, Bello SO, Yahaya AB, Sadiq A. Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. Natl J Physiol Pharm Pharmacol. 2022; 12(4): 395-403. doi:10.5455/njppp.2022.12.01044202203032022

Web Style

Yunusa A, Chika A, Bello SO, Yahaya AB, Sadiq A. Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. https://www.njppp.com/?mno=10365 [Access: January 17, 2025]. doi:10.5455/njppp.2022.12.01044202203032022

AMA (American Medical Association) Style

Yunusa A, Chika A, Bello SO, Yahaya AB, Sadiq A. Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. Natl J Physiol Pharm Pharmacol. 2022; 12(4): 395-403. doi:10.5455/njppp.2022.12.01044202203032022

Vancouver/ICMJE Style

Yunusa A, Chika A, Bello SO, Yahaya AB, Sadiq A. Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. Natl J Physiol Pharm Pharmacol. (2022), [cited January 17, 2025]; 12(4): 395-403. doi:10.5455/njppp.2022.12.01044202203032022

Harvard Style

Yunusa, A., Chika, . A., Bello, . S. O., Yahaya, . A. B. & Sadiq, . A. (2022) Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. Natl J Physiol Pharm Pharmacol, 12 (4), 395-403. doi:10.5455/njppp.2022.12.01044202203032022

Turabian Style

Yunusa, Abdulmajeed, Aminu Chika, Shaibu Oricha Bello, Aisha Bello Yahaya, and Abubakar Sadiq. 2022. Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. National Journal of Physiology, Pharmacy and Pharmacology, 12 (4), 395-403. doi:10.5455/njppp.2022.12.01044202203032022

Chicago Style

Yunusa, Abdulmajeed, Aminu Chika, Shaibu Oricha Bello, Aisha Bello Yahaya, and Abubakar Sadiq. "Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 395-403. doi:10.5455/njppp.2022.12.01044202203032022

MLA (The Modern Language Association) Style

Yunusa, Abdulmajeed, Aminu Chika, Shaibu Oricha Bello, Aisha Bello Yahaya, and Abubakar Sadiq. "Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews." National Journal of Physiology, Pharmacy and Pharmacology 12.4 (2022), 395-403. Print. doi:10.5455/njppp.2022.12.01044202203032022

APA (American Psychological Association) Style

Yunusa, A., Chika, . A., Bello, . S. O., Yahaya, . A. B. & Sadiq, . A. (2022) Clinical effectiveness and tolerability of phytotherapy for benign prostatic hyperplasia - A systematic review of systematic reviews. National Journal of Physiology, Pharmacy and Pharmacology, 12 (4), 395-403. doi:10.5455/njppp.2022.12.01044202203032022

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