E-ISSN 2231-3206 | ISSN 2320-4672
 

Case Report 


Oxaliplatin-induced laryngospasm - A case report

Sarada Kolathu, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, Pavithran Keechilat.

Abstract
Oxaliplatin is third-generation platinum compound used in the treatment of colorectal cancer, gastrointestinal cancers, and few other malignancies. It is mostly used in combination regimens with 5-fluorouracil /leucovorin or capecitabine. Neurotoxicity is the major dose-limiting adverse event. Peripheral neuropathy, predominantly of sensory type occurs in 85-95% of patients. Severe immediate hypersensitivity reactions are very rare and generally occurs after the sixth cycle. Here, we report a 54-year-old female with Stage IV colon cancer who developed jaw muscle spasm, suffocation, and dysphonia during the infusion of 3rd cycle of CAPOX regimen. The reaction lasted up to 1 h even after the infusion was stopped and was managed with steroids and antihistamines. Laryngospam is a very rare side effect, so nursing staff and clinicians should be prepared for the management of such hypersensitivity reactions.

Key words: Colorectal Cancer; Malignancies; Adverse Event; Neurotoxicity; Laryngospasm; Hypersensitivity Reactions


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Sarada Kolathu
Articles by Sandhya Lekshmi S
Articles by Ranjini Pillai
Articles by Neethu C M
Articles by Pavithran Keechilat
on Google
on Google Scholar
Article Statistics
 Viewed: 610
Downloaded: 213
Cited: 0

How to Cite this Article
Pubmed Style

Kolathu S, S SL, Pillai R, M NC, Keechilat P. Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 146-148. doi:10.5455/njppp.2018.8.0726428072017


Web Style

Kolathu S, S SL, Pillai R, M NC, Keechilat P. Oxaliplatin-induced laryngospasm - A case report. http://www.njppp.com/?mno=272819 [Access: April 22, 2018]. doi:10.5455/njppp.2018.8.0726428072017


AMA (American Medical Association) Style

Kolathu S, S SL, Pillai R, M NC, Keechilat P. Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 146-148. doi:10.5455/njppp.2018.8.0726428072017



Vancouver/ICMJE Style

Kolathu S, S SL, Pillai R, M NC, Keechilat P. Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol. (2018), [cited April 22, 2018]; 8(1): 146-148. doi:10.5455/njppp.2018.8.0726428072017



Harvard Style

Kolathu, S., S, S. L., Pillai, R., M, N. C. & Keechilat, P. (2018) Oxaliplatin-induced laryngospasm - A case report. Natl J Physiol Pharm Pharmacol, 8 (1), 146-148. doi:10.5455/njppp.2018.8.0726428072017



Turabian Style

Kolathu, Sarada, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, and Pavithran Keechilat. 2018. Oxaliplatin-induced laryngospasm - A case report. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 146-148. doi:10.5455/njppp.2018.8.0726428072017



Chicago Style

Kolathu, Sarada, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, and Pavithran Keechilat. "Oxaliplatin-induced laryngospasm - A case report." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 146-148. doi:10.5455/njppp.2018.8.0726428072017



MLA (The Modern Language Association) Style

Kolathu, Sarada, Sandhya Lekshmi S, Ranjini Pillai, Neethu C M, and Pavithran Keechilat. "Oxaliplatin-induced laryngospasm - A case report." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 146-148. Print. doi:10.5455/njppp.2018.8.0726428072017



APA (American Psychological Association) Style

Kolathu, S., S, S. L., Pillai, R., M, N. C. & Keechilat, P. (2018) Oxaliplatin-induced laryngospasm - A case report. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 146-148. doi:10.5455/njppp.2018.8.0726428072017





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Most Cited Articles
  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 4 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 4 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 4 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 4 times [Click to see citing articles]

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31
    Cited : 3 times [Click to see citing articles]