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Cardiotoxicity associated with 5-flurouracil A case series

Jisha S Das, Naveen Kumar Panicker.

Abstract
5-flurouracil (5-FU) is a frequently administered chemotherapeutic drug in various malignant neoplasms. We report four cases of cancer patients who were exposed to 5-FU and which resulted in cardio toxicity. Patients developed supraventricular tachycardia, sinus bradycardia, cardiomyopathy, and acute coronary vasospasms. In all cases, the events were reversible. Except in case of cardiomyopathy the chemotherapy was continued without any further issues. All the observed adverse drug reactions (ADR) were carefully studied and the causality was assessed using Naranjo ADR probability scale.

Key words: 5-Flurouracil; Cardiotoxicity; Cardiomyopathy


 
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How to Cite this Article
Pubmed Style

Das JS, Panicker NK. Cardiotoxicity associated with 5-flurouracil A case series. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 149-151. doi:10.5455/njppp.2018.8.0726902082017


Web Style

Das JS, Panicker NK. Cardiotoxicity associated with 5-flurouracil A case series. http://www.njppp.com/?mno=273037 [Access: January 22, 2018]. doi:10.5455/njppp.2018.8.0726902082017


AMA (American Medical Association) Style

Das JS, Panicker NK. Cardiotoxicity associated with 5-flurouracil A case series. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 149-151. doi:10.5455/njppp.2018.8.0726902082017



Vancouver/ICMJE Style

Das JS, Panicker NK. Cardiotoxicity associated with 5-flurouracil A case series. Natl J Physiol Pharm Pharmacol. (2018), [cited January 22, 2018]; 8(1): 149-151. doi:10.5455/njppp.2018.8.0726902082017



Harvard Style

Das, J. S. & Panicker, N. K. (2018) Cardiotoxicity associated with 5-flurouracil A case series. Natl J Physiol Pharm Pharmacol, 8 (1), 149-151. doi:10.5455/njppp.2018.8.0726902082017



Turabian Style

Das, Jisha S, and Naveen Kumar Panicker. 2018. Cardiotoxicity associated with 5-flurouracil A case series. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 149-151. doi:10.5455/njppp.2018.8.0726902082017



Chicago Style

Das, Jisha S, and Naveen Kumar Panicker. "Cardiotoxicity associated with 5-flurouracil A case series." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 149-151. doi:10.5455/njppp.2018.8.0726902082017



MLA (The Modern Language Association) Style

Das, Jisha S, and Naveen Kumar Panicker. "Cardiotoxicity associated with 5-flurouracil A case series." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 149-151. Print. doi:10.5455/njppp.2018.8.0726902082017



APA (American Psychological Association) Style

Das, J. S. & Panicker, N. K. (2018) Cardiotoxicity associated with 5-flurouracil A case series. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 149-151. doi:10.5455/njppp.2018.8.0726902082017



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