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Original Research 


Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis

Zaynutdinovich Khakimov, Alisher Khudayberdievich Rakhmanov, U B Yakubova, Kodir Shukurlaevich Shukurlaev2.

Abstract
Background: Despite the huge number of drugs used for the treatment of inflammatory diseases, the modern assortment of this group of drugs does not solve the problem of their successful therapy and relapses, the frequency of which after stopping the administration can reach high values.

Aim and Objective: The aim of this work was to study the anti-inflammatory activity of a gel containing Convolvulus arvensis in aseptic arthritis induced by carrageenan.

Materials and Methods: Experimental studies were carried out on sexually mature white males’ rats with an initial weight of 155–180 g. A 5% C. arvensis extract containing gel and 5% ibuprofen gel was applied to the surface of the right hind paw of the animals 1 h before the injection of flogogen and after each measurement of the paw volume. Measurement of the paw volume of animals was carried out using a plethysmometer

Results: A more expressed antiexudative effect was observed when used C. arvensis extract-containing gel. Hence, after 1, 2.3, and 4 h from the beginning of the action of carrageenan, the volume of the rat paws increased compared to the initial by 45.5; 51.9; 59.7; and 51.9%, respectively. An almost twofold inhibition of the development of the exudation process was observed under the influence of C. arvensis extract containing gel in comparison with the control group.

Conclusions: The gel containing the extract of C. arvensis has an expressed antiexudative effect in aseptic arthritis induced by carrageenan. In terms of its antiexudative activity, the preparation containing the extract of C. arvensis is not inferior to ibuprofen when applied locally in the form of a gel.

Key words: Inflammation; Carrageenan; Anti-exudative activity of Convolvulus arvensis extract


 
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How to Cite this Article
Pubmed Style

Khakimov Z, Rakhmanov AK, Yakubova UB, Shukurlaev KS. Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. Natl J Physiol Pharm Pharmacol. 2021; 11(6): 645-648. doi:10.5455/njppp.2021.11.03097202117042021


Web Style

Khakimov Z, Rakhmanov AK, Yakubova UB, Shukurlaev KS. Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. http://www.njppp.com/?mno=67129 [Access: October 04, 2021]. doi:10.5455/njppp.2021.11.03097202117042021


AMA (American Medical Association) Style

Khakimov Z, Rakhmanov AK, Yakubova UB, Shukurlaev KS. Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. Natl J Physiol Pharm Pharmacol. 2021; 11(6): 645-648. doi:10.5455/njppp.2021.11.03097202117042021



Vancouver/ICMJE Style

Khakimov Z, Rakhmanov AK, Yakubova UB, Shukurlaev KS. Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. Natl J Physiol Pharm Pharmacol. (2021), [cited October 04, 2021]; 11(6): 645-648. doi:10.5455/njppp.2021.11.03097202117042021



Harvard Style

Khakimov, Z., Rakhmanov, . A. K., Yakubova, . U. B. & Shukurlaev, . K. S. (2021) Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. Natl J Physiol Pharm Pharmacol, 11 (6), 645-648. doi:10.5455/njppp.2021.11.03097202117042021



Turabian Style

Khakimov, Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, U B Yakubova, and Kodir Shukurlaevich Shukurlaev. 2021. Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. National Journal of Physiology, Pharmacy and Pharmacology, 11 (6), 645-648. doi:10.5455/njppp.2021.11.03097202117042021



Chicago Style

Khakimov, Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, U B Yakubova, and Kodir Shukurlaevich Shukurlaev. "Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 645-648. doi:10.5455/njppp.2021.11.03097202117042021



MLA (The Modern Language Association) Style

Khakimov, Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, U B Yakubova, and Kodir Shukurlaevich Shukurlaev. "Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis." National Journal of Physiology, Pharmacy and Pharmacology 11.6 (2021), 645-648. Print. doi:10.5455/njppp.2021.11.03097202117042021



APA (American Psychological Association) Style

Khakimov, Z., Rakhmanov, . A. K., Yakubova, . U. B. & Shukurlaev, . K. S. (2021) Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis. National Journal of Physiology, Pharmacy and Pharmacology, 11 (6), 645-648. doi:10.5455/njppp.2021.11.03097202117042021