E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats

.

Abstract
Background: Some members of the genus Phyllanthus have been widely used in global traditional medicine to manage a variety of liver diseases and experimentally documented to have hepatoprotective activity. However, it is not known whether Phyllanthus pentandrus (PP) (a member of the genus endogenous to Northwestern Nigeria) possesses hepatoprotective properties.

Aims and Objective: The objective was to investigate the hepatoprotective and body weight lowering effects of the aqueous leaf extract of PP using a high-fat diet (HFD)-induced rat model of nonalcoholic fatty liver disease (NAFLD).

Materials and Methods: After obtaining ethical permission from a departmental committee, Wistar rats were randomly assigned to one of the following treatments for 7 weeks: vehicle + normal diet, vehicle + HFD, orlistat + HFD (at 400 mg/1000 g of HFD), or the PP extract +HFD (500 mg/100 g of HFD). Serum levels of liver enzymes (alkaline phosphatase [ALP], aspartate transaminase [AST], and alanine transaminase), conjugated and total bilirubin were determined. Determination of final body weight gain, adipose tissue weight, liver weight, as well as liver histology, was also performed on the animals.

Results: Compared with normal controls, HFD-fed rats exhibited a significant elevation in ALP, severe liver steatosis, body weight gain, and increased adipose tissue mass. Treatment with the PP extract prevented the increase in the level of ALP, reduced the serum level of AST and ameliorated the hepatic steatosis, and adipose tissue gain.

Conclusion: These findings suggest that PP may be beneficial in the management of NAFLD commonly associated with obesity.

Key words: Phyllanthus pentandrus; Fatty Liver; High-Fat Diet; Rats


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by
on Google
on Google Scholar
Article Statistics
 Viewed: 769
Downloaded: 81


How to Cite this Article
Pubmed Style

. Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1251-1256. doi:10.5455/njppp.2019.9.1033818102019


Web Style

. Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. http://www.njppp.com/?mno=5253 [Access: February 15, 2020]. doi:10.5455/njppp.2019.9.1033818102019


AMA (American Medical Association) Style

. Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1251-1256. doi:10.5455/njppp.2019.9.1033818102019



Vancouver/ICMJE Style

. Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. Natl J Physiol Pharm Pharmacol. (2019), [cited February 15, 2020]; 9(12): 1251-1256. doi:10.5455/njppp.2019.9.1033818102019



Harvard Style

(2019) Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. Natl J Physiol Pharm Pharmacol, 9 (12), 1251-1256. doi:10.5455/njppp.2019.9.1033818102019



Turabian Style

. 2019. Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1251-1256. doi:10.5455/njppp.2019.9.1033818102019



Chicago Style

. "Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 1251-1256. doi:10.5455/njppp.2019.9.1033818102019



MLA (The Modern Language Association) Style

. "Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9.12 (2019), 1251-1256. Print. doi:10.5455/njppp.2019.9.1033818102019



APA (American Psychological Association) Style

(2019) Hepatoprotective and body weight lowering effects of the aqueous leaf extract of Phyllanthus pentandrus Schumach. and Thonn (Phyllanthaceae) in nonalcoholic fatty liver disease induced by a high-fat diet in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1251-1256. doi:10.5455/njppp.2019.9.1033818102019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Most Cited Articles
  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 11 times [Click to see citing articles]

  • Pattern of mobile phone usage and its effects on psychological health, sleep, and academic performance in students of a medical university
    Naveenta Gupta, Sonia Garg, Khushdeep Arora
    Natl J Physiol Pharm Pharmacol. 2016; 6(2): 132-139
    » Abstract & References » doi: 10.5455/njppp.2016.6.0311201599
    Cited : 11 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 11 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 10 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 7 times [Click to see citing articles]