E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Pulmonary function tests in thyroid disorders

Laxmi Bhandari, Ruchi Tyagi, Naveen Gaur, Kiran Singh, Prakash Timilsina, Saurabh Singhal, Kaynat Naseer Khan.

Abstract
Background: Worldwide thyroid diseases are one of the most common endocrine disorders. India is also no exception. Thyroid disorders affect all organ systems leading to decreased quality of life and long-term morbidity. The altered levels of thyroid hormone also affect respiratory system. They lead to disorders of respiratory function and disturbances in ventilation.

Aims and Objectives: This study was aimed to explore the respiratory disease pattern in thyroid dysfunction (both hyperthyroid and hypothyroid).

Materials and Methods: After taking clearance from institutional ethical committee, we undertook this case–control observational study. A total of 105 participants were included in the study, 60 euthyroid controls and 45 patients of thyroid disorder (hypothyroid = 30 and hyperthyroid = 15). Convenient sampling technique was used for the study, and simple random sampling technique was used for selecting control groups. Patients were then assessed for thyroid profile. Thyroid-stimulating hormone (TSH), fT3, and fT4 were measured by mini-VIDAS. Once diagnosed with thyroid disorder, these patients were subjected to a battery of pulmonary function test (PFT). We measured the PFT parameters of both cases and controls by SPIRODOC (Spiro PRO6.6 spirometry standard mode, version no. A23-OW-06145). Differences between the study group and controls were examined using SPSS version 19.0. The statistical analysis included one-way ANOVA with Tukey’s Honest Significant Difference post hoc test. Pearson’s correlation was calculated among various parameters. P < 0.05 was considered statistically significant with confidence interval of 95%.

Results: The forced expiratory volume in 1(FEV1)/forced vital capacity (FVC) in euthyroids, hypothyroids, and hyperthyroid was 82.83 ± 1.09, 83.76 ± 2.80, and 83.3 ± 1.77, respectively. FVC in euthyroids was 3.29 ± 0.66, in hypothyroids 2.70 ± 0.52, and in hyperthyroids 2.97 ± 0.48. A restrictive pattern was found in hypothyroid patients whereas we could not find any significant difference in pulmonary functions of hyperthyroid patients when compared with euthyroids. We found a positive linear relation between FEV1 and TSH for both hyperthyroid and hypothyroids (r = 0.54 and r = 0.19, respectively).

Conclusion: Our study shows a restrictive pattern with FEV1/FVC raised in hypothyroid whereas we could not find any statistically significant differences in PFT in hyperthyroid patients.

Key words: Thyroid Function; Pulmonary Function Tests; Hyperthyroid; Hypothyroid


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Laxmi Bhandari
Articles by Ruchi Tyagi
Articles by Naveen Gaur
Articles by Kiran Singh
Articles by Prakash Timilsina
Articles by Saurabh Singhal
Articles by Kaynat Naseer Khan
on Google
on Google Scholar
Article Statistics
 Viewed: 1059
Downloaded: 147
Cited: 0


How to Cite this Article
Pubmed Style

Bhandari L, Tyagi R, Gaur N, Singh K, Timilsina P, Singhal S, Khan KN. Pulmonary function tests in thyroid disorders. Natl J Physiol Pharm Pharmacol. 2019; 9(8): 719-722. doi:10.5455/njppp.2019.9.0414516052019


Web Style

Bhandari L, Tyagi R, Gaur N, Singh K, Timilsina P, Singhal S, Khan KN. Pulmonary function tests in thyroid disorders. http://www.njppp.com/?mno=43920 [Access: December 07, 2019]. doi:10.5455/njppp.2019.9.0414516052019


AMA (American Medical Association) Style

Bhandari L, Tyagi R, Gaur N, Singh K, Timilsina P, Singhal S, Khan KN. Pulmonary function tests in thyroid disorders. Natl J Physiol Pharm Pharmacol. 2019; 9(8): 719-722. doi:10.5455/njppp.2019.9.0414516052019



Vancouver/ICMJE Style

Bhandari L, Tyagi R, Gaur N, Singh K, Timilsina P, Singhal S, Khan KN. Pulmonary function tests in thyroid disorders. Natl J Physiol Pharm Pharmacol. (2019), [cited December 07, 2019]; 9(8): 719-722. doi:10.5455/njppp.2019.9.0414516052019



Harvard Style

Bhandari, L., Tyagi, . R., Gaur, . N., Singh, . K., Timilsina, . P., Singhal, . S. & Khan, . K. N. (2019) Pulmonary function tests in thyroid disorders. Natl J Physiol Pharm Pharmacol, 9 (8), 719-722. doi:10.5455/njppp.2019.9.0414516052019



Turabian Style

Bhandari, Laxmi, Ruchi Tyagi, Naveen Gaur, Kiran Singh, Prakash Timilsina, Saurabh Singhal, and Kaynat Naseer Khan. 2019. Pulmonary function tests in thyroid disorders. National Journal of Physiology, Pharmacy and Pharmacology, 9 (8), 719-722. doi:10.5455/njppp.2019.9.0414516052019



Chicago Style

Bhandari, Laxmi, Ruchi Tyagi, Naveen Gaur, Kiran Singh, Prakash Timilsina, Saurabh Singhal, and Kaynat Naseer Khan. "Pulmonary function tests in thyroid disorders." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 719-722. doi:10.5455/njppp.2019.9.0414516052019



MLA (The Modern Language Association) Style

Bhandari, Laxmi, Ruchi Tyagi, Naveen Gaur, Kiran Singh, Prakash Timilsina, Saurabh Singhal, and Kaynat Naseer Khan. "Pulmonary function tests in thyroid disorders." National Journal of Physiology, Pharmacy and Pharmacology 9.8 (2019), 719-722. Print. doi:10.5455/njppp.2019.9.0414516052019



APA (American Psychological Association) Style

Bhandari, L., Tyagi, . R., Gaur, . N., Singh, . K., Timilsina, . P., Singhal, . S. & Khan, . K. N. (2019) Pulmonary function tests in thyroid disorders. National Journal of Physiology, Pharmacy and Pharmacology, 9 (8), 719-722. doi:10.5455/njppp.2019.9.0414516052019





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Comparison of bleeding time and clotting time between males and females
    Ritu Adhana, Rajanish Chaurasiya, Anjali Verma
    Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1388-1390
    » Abstract » doi: 10.5455/ijmsph.2018.06201417062018

  • Effectiveness of “case-based learning” in physiology
    Amruta S Bennal, Manohar Y Pattar, Raju H Taklikar
    Natl J Physiol Pharm Pharmacol. 2016; 6(1): 65-67
    » Abstract & References » doi: 10.5455/njppp.2015.5.1810201583

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Most Cited Articles
  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 11 times [Click to see citing articles]

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 10 times [Click to see citing articles]

  • Promoting active learning in respiratory physiology – Positive student perception and improved outcomes
    Richa Thaman, Sukhjinder Dhillon, Sanjeev Saggar, Meenakshi Gupta, Harkirat Kaur
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 27-34
    » Abstract & References » doi: 10.5455/njppp.2013.3.27000
    Cited : 10 times [Click to see citing articles]

  • Pattern of mobile phone usage and its effects on psychological health, sleep, and academic performance in students of a medical university
    Naveenta Gupta, Sonia Garg, Khushdeep Arora
    Natl J Physiol Pharm Pharmacol. 2016; 6(2): 132-139
    » Abstract & References » doi: 10.5455/njppp.2016.6.0311201599
    Cited : 8 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 6 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 6 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 6 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation
    Rasha R Ahmed, Ayman M Mahmoud, Mohamed B Ashour, Amira M Kamel
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397
    » Abstract & References » doi: 10.5455/njppp.2015.5.2907201567
    Cited : 6 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 6 times [Click to see citing articles]