E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Inflammation and arterial stiffness in coronary artery disease

Balakrishna Damacharla, Sowjanya B, Aparna R R, Viswakumar R, John Preetham Gurja.

Abstract
Background: Coronary artery disease (CAD) has become endemic in recent times and has become a leading cause of death in India. Atherosclerosis and arterial stiffening are the major sequelae to CAD. Among many risk factors, high sensitive C-reactive protein (hsCRP) has been shown to be strongly associated with CAD and subsequent arterial stiffening. However, there is a paucity of literature of this association in Indian population. Therefore, the present study is aimed to assess the correlation between hsCRP and arterial stiffness in CAD.

Aims and Objectives: The objectives of the study were (i) to asses hsCRP levels in CAD, (ii) to evaluate the arterial stiffness and lipid profile in CAD, and (iii) to correlate hsCRP and arterial stiffness in CAD.

Material and Methods: It is a cross-sectional study of 50 angiographically proven CAD cases and 50 healthy control participants. hsCRP was measured by fluorescent immunoassay using Finecare kit. Pulse wave analysis of augmentation index (AIX) and subendocardial viability ratio (SEVR) was carried out using sphygmocor (EM3). Lipid profile parameters were measured by the enzymatic method. All the measured parameters were analyzed by student “t” test using SPSS version 22.

Results: There is a significant difference in hsCRP levels (P < 0.0001), AIX (P < 0.005), SEVR (P < 0.0001), and high-density lipoprotein (HDL) (P < 0.05) in CAD cases when compared to controls. A positive correlation was observed between hsCRP and AIX and found a negative correlation between hsCRP and HDL.

Conclusion: The present study concludes that there is a significant elevation of hsCRP in established cases of CAD in Indian population. hsCRP and arterial stiffness are strongly associated with CAD independent of hyperlipidemia.

Key words: Coronary Artery Disease; High Sensitive C-reactive Protein; Arterial Stiffness; Augmentation Index; Sub-Endocardial Viability Ratio; Lipid Profile in Coronary Artery Disease


 
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Pubmed Style

Damacharla B, B S, R AR, R V, Gurja JP. Inflammation and arterial stiffness in coronary artery disease. Natl J Physiol Pharm Pharmacol. 2019; 9(5): 418-422. doi:10.5455/njppp.2019.9.0204511022019


Web Style

Damacharla B, B S, R AR, R V, Gurja JP. Inflammation and arterial stiffness in coronary artery disease. http://www.njppp.com/?mno=30405 [Access: August 23, 2019]. doi:10.5455/njppp.2019.9.0204511022019


AMA (American Medical Association) Style

Damacharla B, B S, R AR, R V, Gurja JP. Inflammation and arterial stiffness in coronary artery disease. Natl J Physiol Pharm Pharmacol. 2019; 9(5): 418-422. doi:10.5455/njppp.2019.9.0204511022019



Vancouver/ICMJE Style

Damacharla B, B S, R AR, R V, Gurja JP. Inflammation and arterial stiffness in coronary artery disease. Natl J Physiol Pharm Pharmacol. (2019), [cited August 23, 2019]; 9(5): 418-422. doi:10.5455/njppp.2019.9.0204511022019



Harvard Style

Damacharla, B., B, . S., R, . A. R., R, . V. & Gurja, . J. P. (2019) Inflammation and arterial stiffness in coronary artery disease. Natl J Physiol Pharm Pharmacol, 9 (5), 418-422. doi:10.5455/njppp.2019.9.0204511022019



Turabian Style

Damacharla, Balakrishna, Sowjanya B, Aparna R R, Viswakumar R, and John Preetham Gurja. 2019. Inflammation and arterial stiffness in coronary artery disease. National Journal of Physiology, Pharmacy and Pharmacology, 9 (5), 418-422. doi:10.5455/njppp.2019.9.0204511022019



Chicago Style

Damacharla, Balakrishna, Sowjanya B, Aparna R R, Viswakumar R, and John Preetham Gurja. "Inflammation and arterial stiffness in coronary artery disease." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 418-422. doi:10.5455/njppp.2019.9.0204511022019



MLA (The Modern Language Association) Style

Damacharla, Balakrishna, Sowjanya B, Aparna R R, Viswakumar R, and John Preetham Gurja. "Inflammation and arterial stiffness in coronary artery disease." National Journal of Physiology, Pharmacy and Pharmacology 9.5 (2019), 418-422. Print. doi:10.5455/njppp.2019.9.0204511022019



APA (American Psychological Association) Style

Damacharla, B., B, . S., R, . A. R., R, . V. & Gurja, . J. P. (2019) Inflammation and arterial stiffness in coronary artery disease. National Journal of Physiology, Pharmacy and Pharmacology, 9 (5), 418-422. doi:10.5455/njppp.2019.9.0204511022019





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