Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)

Jose Lorenzo M Barroso, Danalou Claudine G Lacanilao, Renz Anthony C Sac, Rodel Jonathan S Vitor II.

Abstract
Background: The Philippines is one of the countries with high prevalence of diabetes mellitus. Although there are several drugs marketed to control it, there are unwanted side effects. Knowing this, alternative options have been sought for to control the disease.

Aims and Objectives: To evaluate the effects of aqueous extracts of Cycas riuminiana on the blood glucose and cholesterol levels of alloxan-induced diabetic mice.

Materials and Methods: Aqueous crude leaf extract from C. riuminiana was administered to 6 and 30 ICR mice (Mus musculus) to determine whether there are toxic effects and effects on the blood glucose and cholesterol levels, respectively. The 30 mice were divided into six groups and were either treated with double distilled water, glimepiride, or the C. riuminiana aqueous extract.

Results: After performing the acute oral toxicity, there were no deaths signifying that the extracts may be safe to administer in mice. After 28 days of treatment, statistical analyses indicated that the treatment groups had anti-hyperglycemic effects on the diabetic mice. The high-dose group had the lowest mean blood glucose values, which surpassed the hypoglycemic effects of the positive control group, which was treated with glimepiride. Furthermore, there was no difference between the control and the treatment groups. On the other hand, blood cholesterol values of the treatment and control groups were within the normal range after the 28 days study.

Conclusion: The results of the study shows that C. riuminiana leaves have antidiabetic properties by lowering glucose and cholesterol levels at doses between 250 and 1000 mg/kg body weight.

Key words: Anticholesteremic; Blood Glucose; Cycas riuminiana; Hemtatology; Hypoglycemic Agents; Mus musculus


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Jose Lorenzo M Barroso
Articles by Danalou Claudine G Lacanilao
Articles by Renz Anthony C Sac
Articles by Rodel Jonathan S Vitor II
on Google
on Google Scholar
Article Statistics
 Viewed: 156
Downloaded: 62
Cited: 0


How to Cite this Article
Pubmed Style

Barroso JLM, Lacanilao DCG, Sac RAC, II RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1390-1396. doi:10.5455/njppp.2017.7.0831714092017


Web Style

Barroso JLM, Lacanilao DCG, Sac RAC, II RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). http://www.njppp.com/?mno=275162 [Access: December 18, 2017]. doi:10.5455/njppp.2017.7.0831714092017


AMA (American Medical Association) Style

Barroso JLM, Lacanilao DCG, Sac RAC, II RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1390-1396. doi:10.5455/njppp.2017.7.0831714092017



Vancouver/ICMJE Style

Barroso JLM, Lacanilao DCG, Sac RAC, II RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol. (2017), [cited December 18, 2017]; 7(12): 1390-1396. doi:10.5455/njppp.2017.7.0831714092017



Harvard Style

Barroso, J. L. M., Lacanilao, D. C. G., Sac, R. A. C. & II, R. J. S. V. (2017) Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol, 7 (12), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017



Turabian Style

Barroso, Jose Lorenzo M, Danalou Claudine G Lacanilao, Renz Anthony C Sac, and Rodel Jonathan S Vitor II. 2017. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017



Chicago Style

Barroso, Jose Lorenzo M, Danalou Claudine G Lacanilao, Renz Anthony C Sac, and Rodel Jonathan S Vitor II. "Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017



MLA (The Modern Language Association) Style

Barroso, Jose Lorenzo M, Danalou Claudine G Lacanilao, Renz Anthony C Sac, and Rodel Jonathan S Vitor II. "Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)." National Journal of Physiology, Pharmacy and Pharmacology 7.12 (2017), 1390-1396. Print. doi:10.5455/njppp.2017.7.0831714092017



APA (American Psychological Association) Style

Barroso, J. L. M., Lacanilao, D. C. G., Sac, R. A. C. & II, R. J. S. V. (2017) Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2016: 109)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.