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Original Research Open Access


Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats

Sangeetha A, Surapaneni Krishna Mohan, Kumaresan M.

Abstract
Background: Stress and increase in free radicals levels are known to alter cognition, learning, memory, and emotional responses. There is a marked impairment of hippocampus-dependent memory and suppression of long-term potentiation in the CA1 region of the hippocampus during stress.

Aim and Objective: The aim of this study is to evaluate the hypothesized neuroprotective effect of oral antioxidants and piracetam in chronic restraint stress-induced rats.

Materials and Methods: Healthy Wistar rats were divided into 5 groups (n = 6) each. Control group received neither stress nor oral antioxidant. Stress group received chronic restraint stress for 6 h per day for 21 days. Three experimental groups were administered vitamin C (100 mg/kg), beta-carotene (7 mg/kg), and caffeine (8 mg/kg), respectively. Evaluation parameters were measurement of serum nerve growth factor (NGF) using ELISA method. The oxidative stress markers, glutathione peroxidase (GPx), glutathione reductase, and malondialdehyde were measured. Histological analysis of CA1 region of the hippocampus was done to evaluate the structural changes of pyramidal neurons.

Results: Vitamin C caused statistically significant (P < 0.001) increase in serum NGF. The results revealed that vitamin C caused statistically significant (P < 0.05) increase in antioxidant enzymes GPx, glutathione reductase. Vitamin C caused increase in neuronal cell size and volume in CA1 pyramidal layer of hippocampus.

Conclusion: The findings of study are suggestive of neuroprotection, offered by administration of vitamin C compared to other antioxidants against chronic restraint stress-induced rats. These naturally available dietary vitamins might serve as an adjuvant therapy to avoid progression of brain damage during stress.

Key words: Nerve Growth Factor; Vitamin C; Beta-Carotene; Caffeine; Pyramidal Neurons


 
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How to Cite this Article
Pubmed Style

A S, Mohan SK, M K. Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



Web Style

A S, Mohan SK, M K. Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. www.scopemed.org/?mno=269828 [Access: November 22, 2017]. doi:10.5455/njppp.2017.7.0621123062017



AMA (American Medical Association) Style

A S, Mohan SK, M K. Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



Vancouver/ICMJE Style

A S, Mohan SK, M K. Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. Natl J Physiol Pharm Pharmacol. (2017), [cited November 22, 2017]; 7(11): 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



Harvard Style

A, S., Mohan, S. K. & M, K. (2017) Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. Natl J Physiol Pharm Pharmacol, 7 (11), 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



Turabian Style

A, Sangeetha, Surapaneni Krishna Mohan, and Kumaresan M. 2017. Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



Chicago Style

A, Sangeetha, Surapaneni Krishna Mohan, and Kumaresan M. "Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



MLA (The Modern Language Association) Style

A, Sangeetha, Surapaneni Krishna Mohan, and Kumaresan M. "Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats." National Journal of Physiology, Pharmacy and Pharmacology 7.11 (2017), 1190-1194. Print. doi:10.5455/njppp.2017.7.0621123062017



APA (American Psychological Association) Style

A, S., Mohan, S. K. & M, K. (2017) Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1190-1194. doi:10.5455/njppp.2017.7.0621123062017



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