E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A mathematical approach in the management of hydrocephalus from tuberculous meningitis

Gerard Raimon M Saranza, Derick Erl P Sumalapao, Julette Marie F Batara, Carlene P Arceo.

Abstract
Background: The unavailability of standardized treatment algorithms to properly select tuberculous meningitis (TBM) patients for surgery delays optimal management.

Aim and Objective: This study developed a mathematical model as an objective guide in deciding whether to perform surgical intervention or not among patients with hydrocephalus from TBM.

Materials and Methods: Using 13 different clinical and cerebrospinal fluid parameters, a saturated logistic regression model was developed and tried retrospectively on 37 previously managed cases of hydrocephalus from TBM.

Results: The model is statistically significant (P = 0.0170) with 93.2% concordance index in predicting physician’s decision on admission whether the patient will undergo surgical intervention or not. Patients are recommended for surgical intervention if g-score >0.04 with 90.48% sensitivity.

Conclusion: With its significant P-value and high concordance index, the model is a good representative of the actual decision making of physicians in the management of hydrocephalus from TBM.

Key words: Hydrocephalus; Tuberculous Meningitis; Shunt; Surgery; Mathematical Model; Logistic Regression


 
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Pubmed Style

Saranza GRM, Sumalapao DEP, Batara JMF, Arceo CP. A mathematical approach in the management of hydrocephalus from tuberculous meningitis. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1195-1200. doi:10.5455/njppp.2017.7.0517402072017


Web Style

Saranza GRM, Sumalapao DEP, Batara JMF, Arceo CP. A mathematical approach in the management of hydrocephalus from tuberculous meningitis. http://www.njppp.com/?mno=266945 [Access: October 21, 2018]. doi:10.5455/njppp.2017.7.0517402072017


AMA (American Medical Association) Style

Saranza GRM, Sumalapao DEP, Batara JMF, Arceo CP. A mathematical approach in the management of hydrocephalus from tuberculous meningitis. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1195-1200. doi:10.5455/njppp.2017.7.0517402072017



Vancouver/ICMJE Style

Saranza GRM, Sumalapao DEP, Batara JMF, Arceo CP. A mathematical approach in the management of hydrocephalus from tuberculous meningitis. Natl J Physiol Pharm Pharmacol. (2017), [cited October 21, 2018]; 7(11): 1195-1200. doi:10.5455/njppp.2017.7.0517402072017



Harvard Style

Saranza, G. R. M., Sumalapao, D. E. P., Batara, J. M. F. & Arceo, C. P. (2017) A mathematical approach in the management of hydrocephalus from tuberculous meningitis. Natl J Physiol Pharm Pharmacol, 7 (11), 1195-1200. doi:10.5455/njppp.2017.7.0517402072017



Turabian Style

Saranza, Gerard Raimon M, Derick Erl P Sumalapao, Julette Marie F Batara, and Carlene P Arceo. 2017. A mathematical approach in the management of hydrocephalus from tuberculous meningitis. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1195-1200. doi:10.5455/njppp.2017.7.0517402072017



Chicago Style

Saranza, Gerard Raimon M, Derick Erl P Sumalapao, Julette Marie F Batara, and Carlene P Arceo. "A mathematical approach in the management of hydrocephalus from tuberculous meningitis." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1195-1200. doi:10.5455/njppp.2017.7.0517402072017



MLA (The Modern Language Association) Style

Saranza, Gerard Raimon M, Derick Erl P Sumalapao, Julette Marie F Batara, and Carlene P Arceo. "A mathematical approach in the management of hydrocephalus from tuberculous meningitis." National Journal of Physiology, Pharmacy and Pharmacology 7.11 (2017), 1195-1200. Print. doi:10.5455/njppp.2017.7.0517402072017



APA (American Psychological Association) Style

Saranza, G. R. M., Sumalapao, D. E. P., Batara, J. M. F. & Arceo, C. P. (2017) A mathematical approach in the management of hydrocephalus from tuberculous meningitis. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1195-1200. doi:10.5455/njppp.2017.7.0517402072017





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