Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats

Mahesh Basanagauda Mudhol; Surendra Kumar Gondi; Reddyprasad C

doi:10.5455/njppp.2024.14.01017202416012024

2024, Vol: 14, Issue: 5

14 / 5Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
30 / 01 / 2024

Natl J Physiol Pharm Pharmacol. 2024; 14(2): 302-306

doi: 10.5455/njppp.2024.14.01017202416012024

Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats

Mahesh Basanagauda Mudhol, Surendra Kumar Gondi, Reddyprasad C.

Abstract
Background: Thiophene, also known as thiofuran, is a heterocyclic molecule represented by the chemical formula C4H4S.

Aim and Objectives: The aim of this study was to evaluate the anti-inflammatory activity of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound in Wistar rats by acute carrageenan-induced paw edema and chronic cotton pellet-induced granuloma methods.

Materials and Methods: This study consists of two stages: An acute inflammation study using carrageenan-induced paw edema in rats, which involves four groups of rats, and a chronic inflammation study using cotton pellet-induced granuloma, which involves three groups of rats. Mean paw edema volume and percentage of inhibition were measured in acute stage. The mean weight of the pellets in each group was determined during the chronic stage.

Results: There was increase in the mean paw volume at 3 h and a slow decrease at 6 h and 24 h in control group to thiophene derivative-20 mg/kg/p.o from 0 h to 24 h. The mean difference from control and at 3 h, 6 h, and 24 h showed that mean difference was slowly decreased and it was statistically significant. The mean dry granuloma weight in control group, i.e., 10% tween 80 treated group was 146.6 ± 4.38. The mean dry granuloma weight in standard group, i.e., indomethacin 3 mg/kg treated group was 87.7 ± 3.41. The mean dry granuloma weight in substituted thiophene 10 mg/kg group was 101.91 ± 3.76.

Conclusions: The newly synthesized substituted (fused) thiophene compound demonstrated inhibition of inflammation in both acute inflammation induced by carrageenan-induced paw edema and chronic inflammation induced by cotton pellet-induced granuloma in Wistar rats. The compound’s anti-inflammatory effects were comparable to those of the standard drug indomethacin, with a dosage of 10 mg/kg in the acute model and 3 mg/kg in the chronic inflammation model. This concludes that the test compound has anti-inflammatory activity.

Key words: Thiophene Compound; Acute Carrageenan Induced Paw Edema; Chronic Cotton Pellet Induced Granuloma; Wistar Rats

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Mahesh Basanagauda Mudhol Articles by Surendra Kumar Gondi Articles by Reddyprasad C
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Web Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. https://www.njppp.com/?mno=184700 [Access: March 14, 2024]. doi:10.5455/njppp.2024.14.01017202416012024

AMA (American Medical Association) Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Vancouver/ICMJE Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol. (2024), [cited March 14, 2024]; 14(2): 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Harvard Style

Mudhol, M. B., Gondi, . S. K. & C, . R. (2024) Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol, 14 (2), 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Turabian Style

Mudhol, Mahesh Basanagauda, Surendra Kumar Gondi, and Reddyprasad C. 2024. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Chicago Style

Mudhol, Mahesh Basanagauda, Surendra Kumar Gondi, and Reddyprasad C. "Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 302-306. doi:10.5455/njppp.2024.14.01017202416012024

MLA (The Modern Language Association) Style

Mudhol, Mahesh Basanagauda, Surendra Kumar Gondi, and Reddyprasad C. "Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats." National Journal of Physiology, Pharmacy and Pharmacology 14.2 (2024), 302-306. Print. doi:10.5455/njppp.2024.14.01017202416012024

APA (American Psychological Association) Style

Mudhol, M. B., Gondi, . S. K. & C, . R. (2024) Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272