E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test

Devesh D Gosavi, Amit S Kamdi.

Abstract
Background: There are many antidepressant drugs used today have the adverse drug reactions. Withania coagulans – a species to be extinct, is not explored much for its effects on mood except in late seventies. As a result, it was thought worthy to explore antidepressant activities of alcoholic extract of W. coagulans fruits in Swiss albino mice (SAM) using tail suspension test (TST).

Aim and Objective: This study aims to study the alcoholic extract of W. coagulans fruits’ antidepressant effect in SAM by TST.

Materials and Methods: TST was used for evaluating the antidepressant action of W. coagulans fruits alcoholic extract. If the extract had antidepressant action, then it was estimated that the period of mobility would rise and immobility would reduce. This reduction in immobility, if found statistically significant, was considered for antidepressant action.

Results: There was statistically substantial (P < 0.001) association observed between alcoholic extract of W. coagulans fruits with depressant action on mood in SAM by TST.

Conclusion: The alcoholic extract of W. coagulans fruits did not prove antidepressant action in SAM. On the other hand, it showed depressive effect on the mood in the TST.

Key words: Antidepressant; Swiss Albino Mice; Withania coagulans; Tail Suspension Test


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Devesh D Gosavi
Articles by Amit S Kamdi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Gosavi DD, Kamdi AS. The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. Natl J Physiol Pharm Pharmacol. 2020; 10(7): 527-529. doi:10.5455/njppp.2020.10.03080202011042020


Web Style

Gosavi DD, Kamdi AS. The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. http://www.njppp.com/?mno=95509 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.03080202011042020


AMA (American Medical Association) Style

Gosavi DD, Kamdi AS. The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. Natl J Physiol Pharm Pharmacol. 2020; 10(7): 527-529. doi:10.5455/njppp.2020.10.03080202011042020



Vancouver/ICMJE Style

Gosavi DD, Kamdi AS. The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(7): 527-529. doi:10.5455/njppp.2020.10.03080202011042020



Harvard Style

Gosavi, D. D. & Kamdi, . A. S. (2020) The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. Natl J Physiol Pharm Pharmacol, 10 (7), 527-529. doi:10.5455/njppp.2020.10.03080202011042020



Turabian Style

Gosavi, Devesh D, and Amit S Kamdi. 2020. The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. National Journal of Physiology, Pharmacy and Pharmacology, 10 (7), 527-529. doi:10.5455/njppp.2020.10.03080202011042020



Chicago Style

Gosavi, Devesh D, and Amit S Kamdi. "The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 527-529. doi:10.5455/njppp.2020.10.03080202011042020



MLA (The Modern Language Association) Style

Gosavi, Devesh D, and Amit S Kamdi. "The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test." National Journal of Physiology, Pharmacy and Pharmacology 10.7 (2020), 527-529. Print. doi:10.5455/njppp.2020.10.03080202011042020



APA (American Psychological Association) Style

Gosavi, D. D. & Kamdi, . A. S. (2020) The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test. National Journal of Physiology, Pharmacy and Pharmacology, 10 (7), 527-529. doi:10.5455/njppp.2020.10.03080202011042020