E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease

Arpana Bhide, Usha Kalawat, Sivakumar Vishnubhotla.

Abstract
Background: Infections are the main reason for hospitalization and the second common cause of death in chronic kidney disease (CKD) patients. Infections develop primarily as a consequence of deranged innate immunity. In this study, we assessed the efficiency of phagocytic function of polymorphonuclear (PMN) leukocytes in severe CKD patients.

Aims and Objectives: The aims of the study were (i) to assess the phagocytic index and lytic index of PMN leukocytes (PMNLs) in Stages 4 and 5 CKD patients. (ii) To compare the above indices with healthy age and sex-matched controls.

Materials and Methods: The study was carried out in 60 adults in the age group of 18–60 years of which 30 were CKD patients in Stages 4 and 5 taking conservative treatment (not on dialysis) and other 30 were age and sex-matched controls. After screening for inclusion and exclusion criteria, 5 ml of venous blood was collected and taken immediately for evaluation. Phagocytic index which is the number of neutrophils positive for ingested microbes per 100 neutrophils and lytic index which is the total number of microbes per 100 cells were calculated. These are indices of neutrophil functioning.

Results: Statistically significant decrease in both phagocytic index and lytic index were found in Stages 4 and 5 CKD patients as compared to controls.

Conclusion: In the present study, we were able to establish that phagocytic capacity of PMNLs is adversely affected in severe CKD patients. This gains importance in the light of immune dysfunction being considered as a major cause of premature deaths resulting from infections in severe CKD.

Key words: Chronic Kidney Disease; Phagocytic Index; Lytic Index


 
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How to Cite this Article
Pubmed Style

Bhide A, Kalawat U, Vishnubhotla S. Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1172-1175. doi:10.5455/njppp.2019.9.0930415092019


Web Style

Bhide A, Kalawat U, Vishnubhotla S. Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. http://www.njppp.com/?mno=64086 [Access: February 15, 2020]. doi:10.5455/njppp.2019.9.0930415092019


AMA (American Medical Association) Style

Bhide A, Kalawat U, Vishnubhotla S. Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1172-1175. doi:10.5455/njppp.2019.9.0930415092019



Vancouver/ICMJE Style

Bhide A, Kalawat U, Vishnubhotla S. Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. Natl J Physiol Pharm Pharmacol. (2019), [cited February 15, 2020]; 9(12): 1172-1175. doi:10.5455/njppp.2019.9.0930415092019



Harvard Style

Bhide, A., Kalawat, . U. & Vishnubhotla, . S. (2019) Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. Natl J Physiol Pharm Pharmacol, 9 (12), 1172-1175. doi:10.5455/njppp.2019.9.0930415092019



Turabian Style

Bhide, Arpana, Usha Kalawat, and Sivakumar Vishnubhotla. 2019. Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1172-1175. doi:10.5455/njppp.2019.9.0930415092019



Chicago Style

Bhide, Arpana, Usha Kalawat, and Sivakumar Vishnubhotla. "Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 1172-1175. doi:10.5455/njppp.2019.9.0930415092019



MLA (The Modern Language Association) Style

Bhide, Arpana, Usha Kalawat, and Sivakumar Vishnubhotla. "Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease." National Journal of Physiology, Pharmacy and Pharmacology 9.12 (2019), 1172-1175. Print. doi:10.5455/njppp.2019.9.0930415092019



APA (American Psychological Association) Style

Bhide, A., Kalawat, . U. & Vishnubhotla, . S. (2019) Assessment of phagocytic activity of polymorphonuclear leukocytes in hospitalized patients with Stages 4 and 5 chronic kidney disease. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1172-1175. doi:10.5455/njppp.2019.9.0930415092019





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