E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Effect of buspirone on blood glucose levels in rats

Nisharani Jadhav, Anita Deshpande, Ravikumar Baradol.

Abstract
Background: Buspirone is commonly used as an anti-anxiety drug. There is controversy over the dysglycemic effects of buspirone in various clinical and animal studies.

Aims and Objectives: This study aims to evaluate the effect of buspirone on blood sugar level in rats at three different doses.

Materials and Methods: Rats were treated with three doses of buspirone orally, namely, 3 mg/kg, 5 mg/kg, and 10 mg/kg and control group received distilled water orally for 14 days. Blood was collected by tail prick method at 0 h (fasting), at ˝ h, 1 h, 1˝ h, 2 h, and 4 h after drug administration on day 1. On days 7 and 14, the blood glucose levels were estimated at baseline (0 h) and at 1 h after the drug administration. Blood glucose levels were estimated using the glucometer.

Results: On day 1, mean blood glucose values were found to be significantly (P < 0.001) low in control group and in buspirone 3 mg/kg and 5 mg/kg groups at various time intervals as compared to baseline value at 0 h in respective group. In buspirone 10 mg/kg group, mean blood glucose levels at all-time intervals were found to be significantly high (P < 0.01) as compared to baseline value at 0 h. On days 7 and 14, a significant increase in the blood glucose level was observed immediately within 30 min of drug administration and reach maximum value at the end of 1 h only in buspirone 10 mg/kg group. This rise in blood glucose level was not seen in groups receiving buspirone 3 mg/kg and 5 mg/kg.

Conclusion: Buspirone 3 mg/kg and 5 mg/kg does not have any effect on blood glucose levels, while in a high dose of 10 mg/kg causes a significant transient increase in the blood glucose level.

Key words: Buspirone; Blood Glucose; Rats


 
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How to Cite this Article
Pubmed Style

Jadhav N, Deshpande A, Baradol R. Effect of buspirone on blood glucose levels in rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 996-1000. doi:10.5455/njppp.2019.9.0725521072019


Web Style

Jadhav N, Deshpande A, Baradol R. Effect of buspirone on blood glucose levels in rats. http://www.njppp.com/?mno=56251 [Access: February 16, 2020]. doi:10.5455/njppp.2019.9.0725521072019


AMA (American Medical Association) Style

Jadhav N, Deshpande A, Baradol R. Effect of buspirone on blood glucose levels in rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 996-1000. doi:10.5455/njppp.2019.9.0725521072019



Vancouver/ICMJE Style

Jadhav N, Deshpande A, Baradol R. Effect of buspirone on blood glucose levels in rats. Natl J Physiol Pharm Pharmacol. (2019), [cited February 16, 2020]; 9(10): 996-1000. doi:10.5455/njppp.2019.9.0725521072019



Harvard Style

Jadhav, N., Deshpande, . A. & Baradol, . R. (2019) Effect of buspirone on blood glucose levels in rats. Natl J Physiol Pharm Pharmacol, 9 (10), 996-1000. doi:10.5455/njppp.2019.9.0725521072019



Turabian Style

Jadhav, Nisharani, Anita Deshpande, and Ravikumar Baradol. 2019. Effect of buspirone on blood glucose levels in rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 996-1000. doi:10.5455/njppp.2019.9.0725521072019



Chicago Style

Jadhav, Nisharani, Anita Deshpande, and Ravikumar Baradol. "Effect of buspirone on blood glucose levels in rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 996-1000. doi:10.5455/njppp.2019.9.0725521072019



MLA (The Modern Language Association) Style

Jadhav, Nisharani, Anita Deshpande, and Ravikumar Baradol. "Effect of buspirone on blood glucose levels in rats." National Journal of Physiology, Pharmacy and Pharmacology 9.10 (2019), 996-1000. Print. doi:10.5455/njppp.2019.9.0725521072019



APA (American Psychological Association) Style

Jadhav, N., Deshpande, . A. & Baradol, . R. (2019) Effect of buspirone on blood glucose levels in rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 996-1000. doi:10.5455/njppp.2019.9.0725521072019





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