E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models

Tushar Dhawale, Subodh Kumar, Dharmadhikari S.

Abstract
Background: Several antidepressants are currently being used as analgesic in neuropathic pain, but their effect on inflammatory pain is not clear. Few studies have shown that duloxetine also has anti-inflammatory effect along with its antinociceptive activity.

Aims and Objectives: The present study was designed to explore the effect of duloxetine on experimentally induced pain and inflammation in animal models.

Materials and Methods: The albino Wistar rats of either sex were randomly divided into four groups, i.e., control and ibuprofen, with six animals in each group. Analgesia was assessed by hot plate method in rats. Paw edema model in rats after induction with 0.1 mL of 1% carrageenan was used to assess the anti-inflammatory activity. Chronic anti-inflammatory activity was assessed by cotton pellet-induced granuloma. The results obtained were analyzed by analysis of variance followed by Tukey HSD post hoc test.

Results: There was a statistically significant increase in reaction time at all time points compared to control in all treatment groups (ibuprofen and duloxetine) in the hot plate methods. Duloxetine (10 mg/kg) is superior to ibuprofen at every time point as shown by increase in mean reaction time. Duloxetine has also shown significant anti-inflammatory effects compared to control. Ibuprofen was found to cause statistically significant decrease in paw size compared to both control and duloxetine in carrageenan-induced rat paw edema. The anti-inflammatory effect of duloxetine was not significant compared to ibuprofen as seen in cotton pellet-induced granuloma.

Conclusion: The present study showed analgesic and anti-inflammatory effect of duloxetine in dose-dependent matter. Thus, duloxetine may fit to be an agent offering analgesic and anti-inflammatory along with its antidepressant activity.

Key words: Analgesic; Carrageenan; Inflammation


 
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Pubmed Style

Dhawale T, Kumar S, S D. Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 842-846. doi:10.5455/njppp.2019.9.0414207062019


Web Style

Dhawale T, Kumar S, S D. Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. http://www.njppp.com/?mno=51454 [Access: September 20, 2019]. doi:10.5455/njppp.2019.9.0414207062019


AMA (American Medical Association) Style

Dhawale T, Kumar S, S D. Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 842-846. doi:10.5455/njppp.2019.9.0414207062019



Vancouver/ICMJE Style

Dhawale T, Kumar S, S D. Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. Natl J Physiol Pharm Pharmacol. (2019), [cited September 20, 2019]; 9(9): 842-846. doi:10.5455/njppp.2019.9.0414207062019



Harvard Style

Dhawale, T., Kumar, . S. & S, . D. (2019) Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. Natl J Physiol Pharm Pharmacol, 9 (9), 842-846. doi:10.5455/njppp.2019.9.0414207062019



Turabian Style

Dhawale, Tushar, Subodh Kumar, and Dharmadhikari S. 2019. Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 842-846. doi:10.5455/njppp.2019.9.0414207062019



Chicago Style

Dhawale, Tushar, Subodh Kumar, and Dharmadhikari S. "Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 842-846. doi:10.5455/njppp.2019.9.0414207062019



MLA (The Modern Language Association) Style

Dhawale, Tushar, Subodh Kumar, and Dharmadhikari S. "Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models." National Journal of Physiology, Pharmacy and Pharmacology 9.9 (2019), 842-846. Print. doi:10.5455/njppp.2019.9.0414207062019



APA (American Psychological Association) Style

Dhawale, T., Kumar, . S. & S, . D. (2019) Evaluation of analgesic and anti-inflammatory activity of ibuprofen and duloxetine in animal models. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 842-846. doi:10.5455/njppp.2019.9.0414207062019





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