E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
08 / 07 / 2013

 


Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode.


Abstract
Background: Cardiovascular Autonomic Diabetic Neuropathy (CADN) is one of the most important diabetes- associated complications. Reduced heart rate variation (HRV) is the earliest indicator of CADN. The prospect of using time domain analysis of HRV using mental arithmetic as a stressor has for early diagnosis of CADN has not been studied so far.

Aims & Objective: To compare time domain parameters of HRV at rest and during acute mental stress between Type 2 diabetics and non- diabetics.

Materials and Methods: 30 male asymptomatic, Type 2 diabetics with duration of diabetes of 2-8 yrs with RBS ≥ 200 mg/dl or FBS ≥ 126 mg/dl in the age group of 30-65 yrs were chosen as subjects. 30 age and sex matched healthy non-diabetics were chosen as controls. HRV analysis was done using ECG recorded at rest in supine position for 5 min and during 5 min of acute mental stress testing.

Results: At rest standard deviation of all R-R intervals (SDNN), root mean square of successive RR- interval differences (RMSSD), number of intervals differing by > 50ms from adjacent interval (NN50) and percentage of NN50 (pNN50) were significantly less in diabetics as compared to non- diabetics. Mental stress showed increases in HR, SBP and DBP in non-diabetics as well as diabetics but SDNN was significantly less in diabetics as compared to non- diabetics during stress.

Conclusion: Data from the study demonstrated that diabetics with 8-10 yrs history had already developed parasympathetic autonomic neuropathy. Time domain analysis of HRV during mental stress can be used as a valuable tool for early diagnosis of autonomic neuropathy to prevent further complications.

Key words: Heart rate variability, Time Domain Analysis, Cardiovascular Diabetic Autonomic Neuropathy


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Anupama Deepak
Articles by Deepak A N
Articles by Shobha Nallulwar
Articles by Vitthal Khode
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38. doi:10.5455/njppp.2014.4.080720131


Web Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. https://www.njppp.com/?mno=40570 [Access: March 14, 2024]. doi:10.5455/njppp.2014.4.080720131


AMA (American Medical Association) Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38. doi:10.5455/njppp.2014.4.080720131



Vancouver/ICMJE Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol. (2014), [cited March 14, 2024]; 4(1): 34-38. doi:10.5455/njppp.2014.4.080720131



Harvard Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode (2014) Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol, 4 (1), 34-38. doi:10.5455/njppp.2014.4.080720131



Turabian Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. 2014. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. National Journal of Physiology, Pharmacy and Pharmacology, 4 (1), 34-38. doi:10.5455/njppp.2014.4.080720131



Chicago Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. "Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study." National Journal of Physiology, Pharmacy and Pharmacology 4 (2014), 34-38. doi:10.5455/njppp.2014.4.080720131



MLA (The Modern Language Association) Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode. "Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study." National Journal of Physiology, Pharmacy and Pharmacology 4.1 (2014), 34-38. Print. doi:10.5455/njppp.2014.4.080720131



APA (American Psychological Association) Style

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode (2014) Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. National Journal of Physiology, Pharmacy and Pharmacology, 4 (1), 34-38. doi:10.5455/njppp.2014.4.080720131