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Original Research Open Access


Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats

Shohreh Taziki, Vahid Khori, Mehrdad Jahanshahi, Akhtar Seifi, Fatemeh Babakordi Babakordi, Ensehgol Nikmahzar Nikmahzar.

Abstract
Background: Pyrazinamide is a widely used antituberculosis drug. However, associated with its clinical use, hepatotoxicity is a life-threating side effect reported in some patients, but the exact mechanism by which pyrazinamide induces hepatotoxicity is not clear yet.

Aims and Objectives: The present investigation was conducted to study the exact mechanism of subchronic toxicity induced by pyrazinamide and protective role of taurine in rats.

Materials and Methods: Markers such as alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, lipid peroxidation, reactive oxygen species (ROS) formation, hepatocytes glutathione (GSH) content, and apoptosis were examined. Furthermore, pathological changes were evaluated.

Results: The results showed that pyrazinamide administration caused hepatotoxicity as revealed by elevation in ALT and AST levels. Pyrazinamide increased ROS generation and malondialdehyde derivative levels, and also, it reduced intracellular GSH contents. Pyrazinamide induced apoptosis in rats liver tissue.

Conclusion: Administration of taurine effectively decreased the intensity of hepatotoxicity induced by pyrazinamide in rats.

Key words: Taurine; Pyrazinamide; Oxidative Stress; Hepatotoxicity; Apoptosis


 
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How to Cite this Article
Pubmed Style

Taziki S, Khori V, Jahanshahi M, Seifi A, Babakordi FB, Nikmahzar EN. Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. doi:10.5455/njppp.2018.8.0101805022018


Web Style

Taziki S, Khori V, Jahanshahi M, Seifi A, Babakordi FB, Nikmahzar EN. Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. http://www.njppp.com/?mno=288214 [Access: February 23, 2018]. doi:10.5455/njppp.2018.8.0101805022018


AMA (American Medical Association) Style

Taziki S, Khori V, Jahanshahi M, Seifi A, Babakordi FB, Nikmahzar EN. Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. doi:10.5455/njppp.2018.8.0101805022018



Vancouver/ICMJE Style

Taziki S, Khori V, Jahanshahi M, Seifi A, Babakordi FB, Nikmahzar EN. Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. doi:10.5455/njppp.2018.8.0101805022018



Harvard Style

Taziki, S., Khori, V., Jahanshahi, M., Seifi, A., Babakordi, F. B. & Nikmahzar, E. N. (2018) Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. doi:10.5455/njppp.2018.8.0101805022018



Turabian Style

Taziki, Shohreh, Vahid Khori, Mehrdad Jahanshahi, Akhtar Seifi, Fatemeh Babakordi Babakordi, and Ensehgol Nikmahzar Nikmahzar. 2018. Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. doi:10.5455/njppp.2018.8.0101805022018



Chicago Style

Taziki, Shohreh, Vahid Khori, Mehrdad Jahanshahi, Akhtar Seifi, Fatemeh Babakordi Babakordi, and Ensehgol Nikmahzar Nikmahzar. "Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats." doi:10.5455/njppp.2018.8.0101805022018



MLA (The Modern Language Association) Style

Taziki, Shohreh, Vahid Khori, Mehrdad Jahanshahi, Akhtar Seifi, Fatemeh Babakordi Babakordi, and Ensehgol Nikmahzar Nikmahzar. "Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats." doi:10.5455/njppp.2018.8.0101805022018



APA (American Psychological Association) Style

Taziki, S., Khori, V., Jahanshahi, M., Seifi, A., Babakordi, F. B. & Nikmahzar, E. N. (2018) Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats. doi:10.5455/njppp.2018.8.0101805022018



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