Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats

Jayan Pariyani Savaringal; Sanalkumar K B

doi:10.5455/njppp.2018.8.1249201012018

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Online Publishing Date:
10 / 01 / 2018

Natl J Physiol Pharm Pharmacol. 2018; 8(5): 650-657

doi: 10.5455/njppp.2018.8.1249201012018

Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats

Jayan Pariyani Savaringal, Sanalkumar K B.

Abstract
Background: Rhizome of Curcuma longa has many therapeutic implications in traditional Indian medicine. It is used in traditional medicine for flatulence, dyspepsia, and other gastric problems. There is conflicting reports regarding its antiulcer and ulcerogenic potential.

Aims and Objectives: The study is with the aim of determining the gastoprotective effect of C. longa extract on aspirin-induced gastric ulcer in rats.

Materials and Methods: C. longa rhizomes were collected locally. Preparation of extract was done with 50% ethanol using Soxhlet extraction. Albino rats of Wistar strain were used for the study. Aspirin was purchased from Sigma Labs, Mumbai. Anti-ulcer effect of the extract was studied in rats after inducing mucosal damage by aspirin.

Results: It was found that extract of C. longa exhibited significant protection against aspirin-induced ulcer at dose levels of 250-mg/kg, 500-mg/kg, and 1000 mg/kg body weight. There is a dose-dependent increase in the ulcer protective action of the extract.

Conclusion: The present study with extract of C. longa revealed its anti-ulcer activity.

Key words: Curcuma longa; Anti-ulcer; Aspirin; Ulcer Index

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Pubmed Style

Jayan Pariyani Savaringal, Sanalkumar K B. Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. Natl J Physiol Pharm Pharmacol. 2018; 8(5): 650-657. doi:10.5455/njppp.2018.8.1249201012018

Web Style

Jayan Pariyani Savaringal, Sanalkumar K B. Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. https://www.njppp.com/?mno=286548 [Access: March 14, 2024]. doi:10.5455/njppp.2018.8.1249201012018

AMA (American Medical Association) Style

Jayan Pariyani Savaringal, Sanalkumar K B. Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. Natl J Physiol Pharm Pharmacol. 2018; 8(5): 650-657. doi:10.5455/njppp.2018.8.1249201012018

Vancouver/ICMJE Style

Jayan Pariyani Savaringal, Sanalkumar K B. Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. Natl J Physiol Pharm Pharmacol. (2018), [cited March 14, 2024]; 8(5): 650-657. doi:10.5455/njppp.2018.8.1249201012018

Harvard Style

Jayan Pariyani Savaringal, Sanalkumar K B (2018) Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. Natl J Physiol Pharm Pharmacol, 8 (5), 650-657. doi:10.5455/njppp.2018.8.1249201012018

Turabian Style

Jayan Pariyani Savaringal, Sanalkumar K B. 2018. Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. National Journal of Physiology, Pharmacy and Pharmacology, 8 (5), 650-657. doi:10.5455/njppp.2018.8.1249201012018

Chicago Style

Jayan Pariyani Savaringal, Sanalkumar K B. "Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 650-657. doi:10.5455/njppp.2018.8.1249201012018

MLA (The Modern Language Association) Style

Jayan Pariyani Savaringal, Sanalkumar K B. "Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats." National Journal of Physiology, Pharmacy and Pharmacology 8.5 (2018), 650-657. Print. doi:10.5455/njppp.2018.8.1249201012018

APA (American Psychological Association) Style

Jayan Pariyani Savaringal, Sanalkumar K B (2018) Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats. National Journal of Physiology, Pharmacy and Pharmacology, 8 (5), 650-657. doi:10.5455/njppp.2018.8.1249201012018

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