E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit

Shruthi K S, Narendranath Sanji, Chaitali R Raghoji, Guruprasad G, Shashikala G H.

Abstract
Background: Despite significant advancement in neonatal intensive care, the incidence of late-onset neonatal sepsis (LONS) remains a major cause of neonatal morbidity and mortality. The causative organisms and their susceptibility to antibiotics vary in different regions; which forms a basis in the selection of empiric antibiotic in suspected cases of sepsis.

Aims and Objectives: To determine the drug sensitivity pattern of the commonly isolated pathogens in LONS.

Materials and Methods: This study was done after obtaining approval from the Institutional Human Ethical Committee of JJM Medical College Davangere. The blood culture sensitivity data of all neonates admitted and treated as cases of LONS over a period of 2 years (December 2013 to December 2015) at the neonatal intensive care unit of Bapuji Hospital were studied retrospectively.

Results: A total of 212 neonates admitted were suspected cases of LONS. 51.88% of them were blood culture positive, with 78.18% of the isolated organisms being Gram-positive and 24 (21.81%) Gram-negative. The most frequently isolated organism was coagulase-negative Staphylococcus aureus (78.18%) followed by Klebsiella pneumoniae (10.9%). 71.25% of these organisms showed resistance to ampicillin, and 56.25% showed resistance to gentamicin which is the World Health Organization recommended an empirical choice of antibiotics.

Conclusion: Our study has shown an increasing trend of resistance to the commonly prescribed first-line empiric antibiotics such as ampicillin and gentamicin. Hence, periodic surveillance of antibiotic susceptibility is of prime importance to choose the right empiric antibiotic.

Key words: Neonatal Sepsis; Empiric Antibiotics; Antibiotic Sensitivity Pattern


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Shruthi K S
Articles by Narendranath Sanji
Articles by Chaitali R Raghoji
Articles by Guruprasad G
Articles by Shashikala G H
on Google
on Google Scholar
Article Statistics
 Viewed: 645
Downloaded: 267
Cited: 0

How to Cite this Article
Pubmed Style

S SK, Sanji N, Raghoji CR, G G, H SG. A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. Natl J Physiol Pharm Pharmacol. 2018; 8(5): 709-712. doi:10.5455/njppp.2018.8.1145016122017


Web Style

S SK, Sanji N, Raghoji CR, G G, H SG. A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. http://www.njppp.com/?mno=281665 [Access: August 21, 2018]. doi:10.5455/njppp.2018.8.1145016122017


AMA (American Medical Association) Style

S SK, Sanji N, Raghoji CR, G G, H SG. A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. Natl J Physiol Pharm Pharmacol. 2018; 8(5): 709-712. doi:10.5455/njppp.2018.8.1145016122017



Vancouver/ICMJE Style

S SK, Sanji N, Raghoji CR, G G, H SG. A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. Natl J Physiol Pharm Pharmacol. (2018), [cited August 21, 2018]; 8(5): 709-712. doi:10.5455/njppp.2018.8.1145016122017



Harvard Style

S, S. K., Sanji, N., Raghoji, C. R., G, G. & H, S. G. (2018) A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. Natl J Physiol Pharm Pharmacol, 8 (5), 709-712. doi:10.5455/njppp.2018.8.1145016122017



Turabian Style

S, Shruthi K, Narendranath Sanji, Chaitali R Raghoji, Guruprasad G, and Shashikala G H. 2018. A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. National Journal of Physiology, Pharmacy and Pharmacology, 8 (5), 709-712. doi:10.5455/njppp.2018.8.1145016122017



Chicago Style

S, Shruthi K, Narendranath Sanji, Chaitali R Raghoji, Guruprasad G, and Shashikala G H. "A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 709-712. doi:10.5455/njppp.2018.8.1145016122017



MLA (The Modern Language Association) Style

S, Shruthi K, Narendranath Sanji, Chaitali R Raghoji, Guruprasad G, and Shashikala G H. "A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit." National Journal of Physiology, Pharmacy and Pharmacology 8.5 (2018), 709-712. Print. doi:10.5455/njppp.2018.8.1145016122017



APA (American Psychological Association) Style

S, S. K., Sanji, N., Raghoji, C. R., G, G. & H, S. G. (2018) A retrospective study on antibiotic sensitivity pattern of pathogens isolated from blood culture in cases of late-onset neonatal sepsis at a neonatal intensive care unit. National Journal of Physiology, Pharmacy and Pharmacology, 8 (5), 709-712. doi:10.5455/njppp.2018.8.1145016122017





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Most Cited Articles
  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’s disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 6 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138
    Cited : 4 times [Click to see citing articles]

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114
    Cited : 4 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 4 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 4 times [Click to see citing articles]