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Original Research Open Access


Eugenol efficacy in preventing nicotine-induced seizures in mice

Neda Sistani Karampour, Ardeshir Arzi, Soroor Namazifar.

Abstract
Background: Seizure is the most common neurological disorder after stroke. In fact, the seizure is a chronic neurological disorder affected 1-2% of the global population. Given the side effects and toxicity of synthetic drugs, some herbal medicines are currently used in the treatment of seizure.

Aims and Objectives: The aim of this study was to evaluate the effect of Eugenol, a compound extracted from clove plant, which is effective in preventing nicotine-derived seizures in mice.

Materials and Methods: In this study, 64 mice were randomly selected. In the dose-response study, different doses of Eugenol (400, 600, and 800 mg/kg) were intraperitoneally injected to the experimental groups. The negative and positive control groups, respectively, received saline (10 ml/kg) and diazepam (0.15 mg/kg). After 30 min, the animals in all groups received intraperitoneal injections of nicotine (5 mg/kg) followed by the measurements of onset time, duration, and severity of seizures. In time-response examination, the most effective dose of Eugenol (600 mg/kg) was injected into the animals at 15, 30, 45, and 60 min before nicotine injection. Afterward, the onset, severity, and duration of seizure were determined.

Results: The results of the dose-response test showed that Eugenol doses of 400, 600, and 800 mg/kg resulted in increased time of onset, and reduced severity and duration of seizure compared to the saline group. The results of time-response revealed that the best dose was 600 mg/kg and that the best time for Eugenol injection was in 30 min before injection of nicotine.

Conclusion: The results of this study suggest that Eugenol can be effective in controlling nicotine-induces seizures.

Key words: Eugenol; Nicotine; Seizures; Mice


 
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How to Cite this Article
Pubmed Style

Karampour NS, Arzi A, Namazifar S. Eugenol efficacy in preventing nicotine-induced seizures in mice. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



Web Style

Karampour NS, Arzi A, Namazifar S. Eugenol efficacy in preventing nicotine-induced seizures in mice. www.scopemed.org/?mno=271128 [Access: November 22, 2017]. doi:10.5455/njppp.2017.7.0623110072017



AMA (American Medical Association) Style

Karampour NS, Arzi A, Namazifar S. Eugenol efficacy in preventing nicotine-induced seizures in mice. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



Vancouver/ICMJE Style

Karampour NS, Arzi A, Namazifar S. Eugenol efficacy in preventing nicotine-induced seizures in mice. Natl J Physiol Pharm Pharmacol. (2017), [cited November 22, 2017]; 7(11): 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



Harvard Style

Karampour, N. S., Arzi, A. & Namazifar, S. (2017) Eugenol efficacy in preventing nicotine-induced seizures in mice. Natl J Physiol Pharm Pharmacol, 7 (11), 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



Turabian Style

Karampour, Neda Sistani, Ardeshir Arzi, and Soroor Namazifar. 2017. Eugenol efficacy in preventing nicotine-induced seizures in mice. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



Chicago Style

Karampour, Neda Sistani, Ardeshir Arzi, and Soroor Namazifar. "Eugenol efficacy in preventing nicotine-induced seizures in mice." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



MLA (The Modern Language Association) Style

Karampour, Neda Sistani, Ardeshir Arzi, and Soroor Namazifar. "Eugenol efficacy in preventing nicotine-induced seizures in mice." National Journal of Physiology, Pharmacy and Pharmacology 7.11 (2017), 1208-1212. Print. doi:10.5455/njppp.2017.7.0623110072017



APA (American Psychological Association) Style

Karampour, N. S., Arzi, A. & Namazifar, S. (2017) Eugenol efficacy in preventing nicotine-induced seizures in mice. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1208-1212. doi:10.5455/njppp.2017.7.0623110072017



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