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Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro

Hemlata Gupta, Shripad B Deshpande.

Abstract
Background: Bisphenol A (BPA), a chemical used in the manufacture of plastics, has toxic effects on reproductive, developmental, and metabolic systems. It is implicated as a causative factor for infertility. The uterine and tubal contractility play a vital role in fertilization and implantation of zygote. The chronic exposure to BPA on myometrial contractions is not known.

Aims and Objectives: The aim of this study is to examine the effect of chronic ingestion of BPA on rat uterine contractions evoked by acetylcholine.

Materials and Methods: Rats weighing 90-150 g were fed BPA (2 μg/kg/day) or placebo containing pellets (time-matched control; TMC) orally for 28 days. The contractility of the uterus was also assessed in group of rats at the beginning (initial control [IC]). After 28 days, animals showing estrous phase were chosen for in vitro recording of uterine contractions (35 ± 1°C). Evoked contractions to different concentrations of acetylcholine were recorded followed by the effect on spontaneous contractions.

Results: Acetylcholine evoked uterine contractions in vitro in a concentration-dependent manner. The contractions were similar in magnitude in IC and TMC. The uterus from BPA-fed animal exhibited decreased responsiveness to acetylcholine-evoked contractions as compared to TMC. In the presence of acetylcholine, frequency and force of spontaneous contractions increased in a concentration-dependent manner. However, in BPA-fed group, the frequency and force of spontaneous contractions were significantly attenuated.

Conclusions: The results indicate that chronic exposure to BPA decreased the acetylcholine-evoked contractions as well as the spontaneous uterine contractions. The decreased contractility may account for the infertility seen after exposure to BPA.

Key words: Bisphenol A; Acetylch‾ Plastic Chemical; Myometrial Contractility; Infertility


 
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How to Cite this Article
Pubmed Style

Gupta H, Deshpande SB. Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



Web Style

Gupta H, Deshpande SB. Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. www.scopemed.org/?mno=269133 [Access: November 22, 2017]. doi:10.5455/njppp.2017.7.006202120720171



AMA (American Medical Association) Style

Gupta H, Deshpande SB. Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



Vancouver/ICMJE Style

Gupta H, Deshpande SB. Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. Natl J Physiol Pharm Pharmacol. (2017), [cited November 22, 2017]; 7(11): 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



Harvard Style

Gupta, H. & Deshpande, S. B. (2017) Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. Natl J Physiol Pharm Pharmacol, 7 (11), 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



Turabian Style

Gupta, Hemlata, and Shripad B Deshpande. 2017. Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



Chicago Style

Gupta, Hemlata, and Shripad B Deshpande. "Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



MLA (The Modern Language Association) Style

Gupta, Hemlata, and Shripad B Deshpande. "Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro." National Journal of Physiology, Pharmacy and Pharmacology 7.11 (2017), 1219-1223. Print. doi:10.5455/njppp.2017.7.006202120720171



APA (American Psychological Association) Style

Gupta, H. & Deshpande, S. B. (2017) Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1219-1223. doi:10.5455/njppp.2017.7.006202120720171



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