E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients

Sandhya Metta, Umesh G Balgi, Shruti Mohanty, Archana A Dharwadkar.

Abstract
Background: Cigarette smoking is one of the prime contributing factors for atherosclerosis. Chronic cigarette smoking causes disturbances in the electrophysiology of heart and may lead to ventricular arrhythmias. Furthermore, cigarette smoke produces oxidative stress by generating free radicals which is responsible for lipid peroxidation and atherosclerosis.

Aims and Objectives: The present study is aimed at evaluating the electrocardiographic (ECG) changes and plasma malondialdehyde (MDA) levels in smokers suffering from ischemic heart disease (IHD).

Materials and Methods: About 327 male subjects, consisting of 127 healthy subjects and 200 consecutively admitted IHD patients were enrolled for this study and were subsequently divided into two subgroups as smokers and non-smokers consisting of 100 non-smokers and 100 smokers, based on the history of smoking. The healthy control group consisted of 64 smokers and 63 non-smokers. All the subjects underwent ECG recording and evaluation of plasma MDA levels.

Results: 68% of IHD patients had typical ST elevation type of ECG, and out of these, 74% were smokers and 62% were non-smokers. The analysis of normal ECG waves of control group indicated significantly shortened QRS complex (P < 0.001) and shortened ST interval (P < 0.001) in smokers than non-smokers. The plasma MDA levels were observed to be highly significant (P < 0.001) in control smokers and patient smokers in comparison to control non-smokers and patient non-smokers, respectively.

Conclusion: In chronic healthy smokers, the QRS complex and ST segment were found to be shortened indicating incomplete ventricular relaxation indicating that the smokers are at higher risk for greater myocardial damage. Furthermore, the greater lipid peroxidation indicated by higher MDA levels in smokers irrespective of the presence of IHD predisposes them to higher risk of atherosclerosis and higher mortality from IHD.

Key words: Electrocardiogram; Smoking; Ischemic Heart Disease; Lipid Peroxidation


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Sandhya Metta
Articles by Umesh G Balgi
Articles by Shruti Mohanty
Articles by Archana A Dharwadkar
on Google
on Google Scholar
Article Statistics
 Viewed: 733
Downloaded: 205
Cited: 0

How to Cite this Article
Pubmed Style

Metta S, Balgi UG, Mohanty S, Dharwadkar AA. Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1182-1185. doi:10.5455/njppp.2017.7.0619816062017


Web Style

Metta S, Balgi UG, Mohanty S, Dharwadkar AA. Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. http://www.njppp.com/?mno=268842 [Access: July 18, 2018]. doi:10.5455/njppp.2017.7.0619816062017


AMA (American Medical Association) Style

Metta S, Balgi UG, Mohanty S, Dharwadkar AA. Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1182-1185. doi:10.5455/njppp.2017.7.0619816062017



Vancouver/ICMJE Style

Metta S, Balgi UG, Mohanty S, Dharwadkar AA. Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. Natl J Physiol Pharm Pharmacol. (2017), [cited July 18, 2018]; 7(11): 1182-1185. doi:10.5455/njppp.2017.7.0619816062017



Harvard Style

Metta, S., Balgi, U. G., Mohanty, S. & Dharwadkar, A. A. (2017) Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. Natl J Physiol Pharm Pharmacol, 7 (11), 1182-1185. doi:10.5455/njppp.2017.7.0619816062017



Turabian Style

Metta, Sandhya, Umesh G Balgi, Shruti Mohanty, and Archana A Dharwadkar. 2017. Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1182-1185. doi:10.5455/njppp.2017.7.0619816062017



Chicago Style

Metta, Sandhya, Umesh G Balgi, Shruti Mohanty, and Archana A Dharwadkar. "Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1182-1185. doi:10.5455/njppp.2017.7.0619816062017



MLA (The Modern Language Association) Style

Metta, Sandhya, Umesh G Balgi, Shruti Mohanty, and Archana A Dharwadkar. "Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients." National Journal of Physiology, Pharmacy and Pharmacology 7.11 (2017), 1182-1185. Print. doi:10.5455/njppp.2017.7.0619816062017



APA (American Psychological Association) Style

Metta, S., Balgi, U. G., Mohanty, S. & Dharwadkar, A. A. (2017) Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1182-1185. doi:10.5455/njppp.2017.7.0619816062017





Most Viewed Articles
  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • How to write a thesis? [English]
    Swapnil s Agarwal, Preeti Yadav, Krishnadutt Chavali, Lavlesh Kumar
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 86-90
    » Abstract

  • Most Downloaded
  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract & References » doi: 10.5455/njppp.2011.1.1-8

  • Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?
    Jaykaran Charan, Deepak Saxena, Summaiya Mulla
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 78-83
    » Abstract & References » doi: 10.5455/njppp.2012.2.78-83

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract & References » doi: 10.5455/njppp.2013.3.109-114

  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20

  • Antidiabetic activity of alcoholic extract of Neem (Azadirachta Indica) root bark
    Prabhakar Patil, Sudha Patil, Abhay Mane, Sushilkumar Verma
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 142-146
    » Abstract & References » doi: 10.5455/njppp.2013.3.134-138

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Most Cited Articles
  • A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in Wistar rats.
    Chetankumar R. Acharya, Hetal N. Thakar, S. K. Vajpeyee
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 14-20
    » Abstract & References » doi: 10.5455/njppp.2013.3.14-20
    Cited : 8 times [Click to see citing articles]

  • A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
    Abhishek Pathak, Lalit Prashant Meena, Jaya Chakravarty, Madhukar Rai, Shyam Sundar
    Natl J Physiol Pharm Pharmacol. 2015; 5(1): 33-35
    » Abstract & References » doi: 10.5455/njppp.2015.5.120720142
    Cited : 6 times [Click to see citing articles]

  • Newer anti-platelet and anti-thrombotic drugs on the horizon
    Ajai Garg, Anjana Pandey, Pranab Oza, Mridul Chaturvedi
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 105-110
    » Abstract & References » doi: 10.5455/njppp.2013.3.090420131
    Cited : 5 times [Click to see citing articles]

  • Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy
    Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal
    Natl J Physiol Pharm Pharmacol. 2013; 3(1): 43-47
    » Abstract & References » doi: 10.5455/njppp.2013.3.43-47
    Cited : 4 times [Click to see citing articles]

  • Effects of sixteen weeks exercise training on left ventricular dimensions and function in young athletes
    Sandip M Hulke, Yuganti P Vaidya, Amandeepkour R Ratta
    Natl J Physiol Pharm Pharmacol. 2012; 2(2): 152-158
    » Abstract & References » doi: 10.5455/njppp.2012.2.152-158
    Cited : 4 times [Click to see citing articles]

  • Prevalence and risk factors for eating disorders in Indian adolescent females
    Amit A Upadhyah, Rajesh Misra, Deepak N Parchwani, Pankaj B Maheria
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 153-157
    » Abstract & References » doi: 10.5455/njppp.2014.4.041220131
    Cited : 4 times [Click to see citing articles]

  • Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
    Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode
    Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38
    » Abstract & References » doi: 10.5455/njppp.2014.4.080720131
    Cited : 4 times [Click to see citing articles]

  • Ratio of second to fourth digit as a predictor of performance in elite Indian volley ball players
    Kaninika Panda, Pralay Majumdar, Veena Umesh, HH Sudhakar
    Natl J Physiol Pharm Pharmacol. 2014; 4(2): 106-108
    » Abstract & References » doi: 10.5455/njppp.2014.4.011020132
    Cited : 4 times [Click to see citing articles]

  • Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimerís disease
    Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri
    Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415
    » Abstract & References » doi: 10.5455/njppp.2015.5.2308201563
    Cited : 4 times [Click to see citing articles]

  • Second MBBS medical student’s feedback on teaching methodology and evaluation methods in Pharmacology
    Nilesh Chavda, Preeti Yadav, Jay Karan, N. D. Kantharia
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 23-31
    » Abstract & References » doi: 10.5455/njppp.2011.1.23-31
    Cited : 3 times [Click to see citing articles]