Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy

Rajeev Kumar Sharma, Bhawana Sharma, Meenakshi Jindal, Arvind Kumar Gupta, Ramesh Kunwar, Suman Lata, Awadhesh Kumar Yadav.

Abstract
Background: Diabetes mellitus (DM) is one of the oldest common metabolic disorders characterized by hyperglycemia, hyperlipidemia, negative nitrogen balance, and ketonemia. It is a one of the most important pathological conditions associated with dyslipidemia that affects the whole body system. Several types of DM exist and result by a complex interaction of genes and drugs, gestational diabetes, environmental factors such as stress and sedentary lifestyle choices. DM is the leading cause of end-stage renal disease, coronary artery disease, cerebrovascular disease, nontraumatic lower extremity amputations, and adult blindness.

Aims and Objectives: This study was conducted to evaluate the hypolipidemic effect of stem part of Berberis aristata in patients of Type 2 DM with dyslipidemia as add on therapy.

Materials and Methods: A prospective randomized open parallel group study was conducted in total 90 patients having high fasting blood sugar (FBS) and dyslipidemia of either sex in the age group of 30-60 years attending of outpatient/indoor Department of Medicine of Muzaffarnagar Medical College and Hospital, Muzaffarnagar, Uttar Pradesh, India. A total of 103 each Group 1 (N = 30) was taken as control while Group 2 (N = 30) and Group 3 (N = 30) was taken as study group who had received 1.5 and 3 g of B. aristata, respectively, as add on therapy along with their conventional antidiabetic and antihyperlipidemic (in certain number of patients) treatment. During the study, 13 patients (8 male and 5 female) did not complete the study and reason of premature withdrawal included protocol violation.

Results: In our study, there were a statistically a highly significant improvement and stabilization of glycemic control in test Groups 2 and 3 when compared with control group (P < 0.01). In Groups 2 and 3, reduction of FBS level from 1 month onward. The mean high density lipoprotein level improved significantly in the Group 2 (P < 0.01) and highly significantly in Group 3 (P < 0.001) as compared to control. The mean total cholesterol level decreased no significantly in the Group 2 (P > 0.05) and highly significant in Group 3 (P < 0.001) as compared to control. The mean triglyceride level decreased highly significantly in the Group 2 and Group 3 (P < 0.001) as compared to control. The mean low density lipoprotein level decreased highly significant in the Group 2 and Group 3 (P < 0.001) as compared to control.

Conclusion: It can be concluded that B. aristata as an add on therapy in Type 2 DM patients has a beneficial role with regard to the hyperglycemia and dyslipidemia very safe as no major side effects were observed affecting morbidity and mortality. Hence, B. aristata as an add on therapy could represent a good treatment option before initiating insulin and hypolipidemic therapy in diabetic patient with suboptional glycemic and lipideimic control to avoid unwanted adverse effects and can cut down cost of treatment.

Key words: Type 2 Diabetes Mellitus; Dyslipidemia Berberis aristata; Add on Therapy


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Rajeev Kumar Sharma
Articles by Bhawana Sharma
Articles by Meenakshi Jindal
Articles by Arvind Kumar Gupta
Articles by Ramesh Kunwar
Articles by Suman Lata
Articles by Awadhesh Kumar Yadav
on Google
on Google Scholar
Article Statistics
 Viewed: 182
Downloaded: 32
Cited: 0


How to Cite this Article
Pubmed Style

Sharma RK, Sharma B, Jindal M, Gupta AK, Kunwar R, Lata S, Yadav AK. Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



Web Style

Sharma RK, Sharma B, Jindal M, Gupta AK, Kunwar R, Lata S, Yadav AK. Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. www.scopemed.org/?mno=264968 [Access: November 22, 2017]. doi:10.5455/njppp.2017.7.0517510062017



AMA (American Medical Association) Style

Sharma RK, Sharma B, Jindal M, Gupta AK, Kunwar R, Lata S, Yadav AK. Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. Natl J Physiol Pharm Pharmacol. 2017; 7(11): 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



Vancouver/ICMJE Style

Sharma RK, Sharma B, Jindal M, Gupta AK, Kunwar R, Lata S, Yadav AK. Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. Natl J Physiol Pharm Pharmacol. (2017), [cited November 22, 2017]; 7(11): 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



Harvard Style

Sharma, R. K., Sharma, B., Jindal, M., Gupta, A. K., Kunwar, R., Lata, S. & Yadav, A. K. (2017) Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. Natl J Physiol Pharm Pharmacol, 7 (11), 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



Turabian Style

Sharma, Rajeev Kumar, Bhawana Sharma, Meenakshi Jindal, Arvind Kumar Gupta, Ramesh Kunwar, Suman Lata, and Awadhesh Kumar Yadav. 2017. Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



Chicago Style

Sharma, Rajeev Kumar, Bhawana Sharma, Meenakshi Jindal, Arvind Kumar Gupta, Ramesh Kunwar, Suman Lata, and Awadhesh Kumar Yadav. "Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



MLA (The Modern Language Association) Style

Sharma, Rajeev Kumar, Bhawana Sharma, Meenakshi Jindal, Arvind Kumar Gupta, Ramesh Kunwar, Suman Lata, and Awadhesh Kumar Yadav. "Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy." National Journal of Physiology, Pharmacy and Pharmacology 7.11 (2017), 1159-1169. Print. doi:10.5455/njppp.2017.7.0517510062017



APA (American Psychological Association) Style

Sharma, R. K., Sharma, B., Jindal, M., Gupta, A. K., Kunwar, R., Lata, S. & Yadav, A. K. (2017) Evaluation of hypolipidemic effect of stem part of Berberis aristata in Type 2 diabetes mellitus patients as add on therapy. National Journal of Physiology, Pharmacy and Pharmacology, 7 (11), 1159-1169. doi:10.5455/njppp.2017.7.0517510062017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2016: 109)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.