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In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia

Ramana Murty Kadali SLDV, Mangala Charan Das, Rajagopalan Vijayaraghavan, Ittagi Shanmukha.

Abstract
Background: Chloroxylon swietenia belongs to family Rutaceae. Common name - satin wood, Telugu name - billedu, bildu chettu, billu, Tamil name - vaaimaram or porasu. C. swietenia has been reported to have anti-inflammatory activity, antimicrobial activity, anthelmintic activity, analgesic activity, antioxidant activity, and mosquitocidal activity.

Aims and Objective: To evaluate in vitro antidiabetic activity of aqueous and ethanolic leaves extracts of C. swietenia by α-amylase and α-glucosidase enzyme inhibitory assay.

Materials and Methods: About 100, 200, 300, 400, 500 μg concentrations of acarbose, aqueous, and ethanolic leaves extracts of C. swietenia were used for the study. The absorbance values were taken in spectrophotometer at 540 nm and 546 nm for α-amylase and α-glucosidase enzyme, respectively.

Results: The extracts exhibited significant inhibition of α-amylase and α-glucosidase enzyme in dose-dependent manner. Ethanolic extract exhibited more inhibitory activity when compared with aqueous extract.

Conclusion: Results shows considerable α-amylase inhibitory activity as well as α-glucosidase inhibitory activity. The present findings indicate that aqueous and ethanolic leaves extracts of C. swietenia have in vitro antidiabetic activity.

Key words: In Vitro Antidiabetic Activity; Chloroxylon swietenia; α-glucosidase; α-amylase; Acarbose


 
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How to Cite this Article
Pubmed Style

SLDV RMK, Das MC, Vijayaraghavan R, Shanmukha I. In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 486-490. doi:10.5455/njppp.2017.7.1235104012017



Web Style

SLDV RMK, Das MC, Vijayaraghavan R, Shanmukha I. In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. www.scopemed.org/?mno=253154 [Access: May 26, 2017]. doi:10.5455/njppp.2017.7.1235104012017



AMA (American Medical Association) Style

SLDV RMK, Das MC, Vijayaraghavan R, Shanmukha I. In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 486-490. doi:10.5455/njppp.2017.7.1235104012017



Vancouver/ICMJE Style

SLDV RMK, Das MC, Vijayaraghavan R, Shanmukha I. In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. Natl J Physiol Pharm Pharmacol. (2017), [cited May 26, 2017]; 7(5): 486-490. doi:10.5455/njppp.2017.7.1235104012017



Harvard Style

SLDV, R. M. K., Das, M. C., Vijayaraghavan, R. & Shanmukha, I. (2017) In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. Natl J Physiol Pharm Pharmacol, 7 (5), 486-490. doi:10.5455/njppp.2017.7.1235104012017



Turabian Style

SLDV, Ramana Murty Kadali, Mangala Charan Das, Rajagopalan Vijayaraghavan, and Ittagi Shanmukha. 2017. In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 486-490. doi:10.5455/njppp.2017.7.1235104012017



Chicago Style

SLDV, Ramana Murty Kadali, Mangala Charan Das, Rajagopalan Vijayaraghavan, and Ittagi Shanmukha. "In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 486-490. doi:10.5455/njppp.2017.7.1235104012017



MLA (The Modern Language Association) Style

SLDV, Ramana Murty Kadali, Mangala Charan Das, Rajagopalan Vijayaraghavan, and Ittagi Shanmukha. "In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia." National Journal of Physiology, Pharmacy and Pharmacology 7.5 (2017), 486-490. Print. doi:10.5455/njppp.2017.7.1235104012017



APA (American Psychological Association) Style

SLDV, R. M. K., Das, M. C., Vijayaraghavan, R. & Shanmukha, I. (2017) In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 486-490. doi:10.5455/njppp.2017.7.1235104012017



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