E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Anticonvulsant activity of gabapentin in mice - An experimental study

Amit P Patel, Shashwat Verma, Pradeep R Jadhav, Y A Deshmukh.

Abstract
Background: Gabapentin (GBP) is used as an adjuvant drug in the treatment of partial seizures. However, there exist limited data demonstrating its antiepileptic activity in generalized seizures.

Aims and Objectives: This study aims to evaluate the anticonvulsant activity of GBP using experimental models in mice.

Materials and Methods: The study was conducted after the Institutional Animal Ethics Committee approval. Anticonvulsant activity of GBP in mice was evaluated against maximal electroshock (MES) and pentylenetetrazol (PTZ)-induced convulsions. MES is a standard model used to evaluate drugs which are effective in grand mal epilepsy, whereas PTZ is used to evaluate drugs effective in petit mal epilepsy. A total of 12 mice were assessed in each model, six mice in each group for control and test. The control group was administered 0.2 ml normal saline single dose per day i.p and test group was administered GBP (0.468 mg/g body wt. of mice) single dose per day i.p for 5 consecutive days. On the 5th day, the anticonvulsant activities were evaluated using both models.

Results: In MES model, we observed 83.34% protection against tonic hind limb extension (THE) in GBP group while there was 0% in control group. However, in PTZ model, GBP was ineffective in preventing seizures but was effective in reducing the severity of seizures and mortality (16.67%) compared to control (100%).

Conclusion: The results obtained showed that GBP significantly inhibited generalized seizures (protection against THE) induced through MES. However, GBP has partial protective effect on PTZ-induced seizures.

Key words: Gabapentin; Antiepileptic; Generalized Seizures; Maximal Electroshock-induced Convulsions; Pentylenetetrazol-induced Convulsions; Experimental Model


 
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Pubmed Style

Patel AP, Verma S, Jadhav PR, Deshmukh YA. Anticonvulsant activity of gabapentin in mice - An experimental study. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 117-120. doi:10.5455/njppp.2019.9.0724205122018


Web Style

Patel AP, Verma S, Jadhav PR, Deshmukh YA. Anticonvulsant activity of gabapentin in mice - An experimental study. http://www.njppp.com/?mno=1301 [Access: April 26, 2019]. doi:10.5455/njppp.2019.9.0724205122018


AMA (American Medical Association) Style

Patel AP, Verma S, Jadhav PR, Deshmukh YA. Anticonvulsant activity of gabapentin in mice - An experimental study. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 117-120. doi:10.5455/njppp.2019.9.0724205122018



Vancouver/ICMJE Style

Patel AP, Verma S, Jadhav PR, Deshmukh YA. Anticonvulsant activity of gabapentin in mice - An experimental study. Natl J Physiol Pharm Pharmacol. (2019), [cited April 26, 2019]; 9(2): 117-120. doi:10.5455/njppp.2019.9.0724205122018



Harvard Style

Patel, A. P., Verma, . S., Jadhav, . P. R. & Deshmukh, . Y. A. (2019) Anticonvulsant activity of gabapentin in mice - An experimental study. Natl J Physiol Pharm Pharmacol, 9 (2), 117-120. doi:10.5455/njppp.2019.9.0724205122018



Turabian Style

Patel, Amit P, Shashwat Verma, Pradeep R Jadhav, and Y A Deshmukh. 2019. Anticonvulsant activity of gabapentin in mice - An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 117-120. doi:10.5455/njppp.2019.9.0724205122018



Chicago Style

Patel, Amit P, Shashwat Verma, Pradeep R Jadhav, and Y A Deshmukh. "Anticonvulsant activity of gabapentin in mice - An experimental study." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 117-120. doi:10.5455/njppp.2019.9.0724205122018



MLA (The Modern Language Association) Style

Patel, Amit P, Shashwat Verma, Pradeep R Jadhav, and Y A Deshmukh. "Anticonvulsant activity of gabapentin in mice - An experimental study." National Journal of Physiology, Pharmacy and Pharmacology 9.2 (2019), 117-120. Print. doi:10.5455/njppp.2019.9.0724205122018



APA (American Psychological Association) Style

Patel, A. P., Verma, . S., Jadhav, . P. R. & Deshmukh, . Y. A. (2019) Anticonvulsant activity of gabapentin in mice - An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 117-120. doi:10.5455/njppp.2019.9.0724205122018





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