E-ISSN 2231-3206 | ISSN 2320-4672
|Original Research|| |
Platelet aggregation and clotting time in type 2 diabetic males
Sunita Dhule, Swati Gawali.
|Cited By: 3|
Background: Diabetes mellitus is a heterogeneous disorder that affects cellular metabolism in variety of ways and coagulation indices are reported to be adversely affected.Insulin resistance is a marked pathophysiology of Type II diabetes causing abnormalities in the microvascular and macrovascular circulations. The entire coagulation cascade is dysfunctional in such condition. Platelets may assume an important role in atherosclerosis in diabetes. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are haematological indices that give an idea about the coagulation status of patients. Hence the present study is undertaken to see the effect of diabetes on platelet aggregation and coagulation parameters like PT and APTT.
Aims & Objective: To study platelet aggregation and clotting time (PT, APTT) in type II diabetic males.
Materials and Methods: The present study included 30 type II diabetic males and 30 normal male subjects. Platelet aggregation was studied by O Brein J R method using ADP reagent. Clotting time (prothrombin time, activated partial thromboplastin time) was estimated by using coagulometer.
Results: ADP induced platelet aggregation was significantly higher while PT and APTT were significantly lower in diabetic group compared with control group (p<0.05) by applying unpaired ‘t’ test.
Conclusion: Our study showed increased platelet agreeability and decreased PT, APTT in type II diabetic males. So, type II diabetic patients are more prone to diseases such as coronary artery disease, cerebrovascular disease and peripheral vascular disease.
Diabetes Mellitus; Platelet Aggregation; Prothrombin Time (PT); Activated Partial Thromboplastin Time (APTT); Insulin
|1.Balasubramaniam GV.Nagalakshmi V, Anand D. A pilot study on platelets in type II Diabetes Mellitus. Indian J Med Healthcare. 2012;1(3):46-49.|
|2.Ferroni P, Basili S, Falco A, Davi G. Platelet activation in type 2 diabetes mellitus. J Thromb Haemost. 2004; 2: 1282–91.|
|3.Guven, F. , Yilmaz, A. , Aydin, H. and Korkmaz, I. (2010) Platelet aggregation responses in type 2 diabetic patients. Health. 2010;2(7):708-712. [DOI via Crossref] |
|4.Vinik AI, Erbas T, Park TS, Nolan R, Pittenger GL. Platelet Dysfunction in Type 2.Diabetes Care. 2001;24(8):1476-85. [DOI via Crossref] [Pubmed] |
|5.Abdulrahaman Y, Dallatu MK. Evaluation of Prothrombin Time and Activated Partial Thromboplastin in Patients with Diabetes Mellitus. Nigerian Journal of Basic and Applied Science. 2012;20(1): 60-63.|
|6.Sauls DL, Banini AE, Boyd LC, Hoffman M. Elevated prothrombin level and shortened clotting times in subjects with type 2 diabetes. J Thromb Haemost. 2007; 5: 638–9.|
|7.Zhao Y, Zhang J, Zhang J, Wu J. Diabetes Mellitus Is Associated with Shortened Activated Partial Thromboplastin Time and Increased Fibrinogen Values. PLoS One. 2011;6(1):e16470. [DOI via Crossref] [Pubmed] [PMC Free Fulltext] |
|8.Korte W, Clarke S, Lefkowitz JB. Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism. Am J Clin Pathol. 2000;113: 123–127.|
|9.Hassan FM. Prothrombin Time and Activated PartialThromboplastin Time among type 2 non-insulin dependent Diabetes Mellitus.Recent Journal in Science and Technology.2009;1(3):131-133.|
|10.Carr ME.Diabetes mellitus: A hypercoagulable state. J Diabetes Complications.2001;15(1):44-54. [DOI via Crossref] |