Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice

Sugirda P; Henry Daniel Raj T; Divakar R

doi:10.5455/njppp.2022.12.0310920220002042022

2024, Vol: 14, Issue: 4

14 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
09 / 04 / 2022

Natl J Physiol Pharm Pharmacol. 2022; 12(5): 657-661

doi: 10.5455/njppp.2022.12.0310920220002042022

Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice

Sugirda P, Henry Daniel Raj T, Divakar R.

Abstract
Background: Not all second-generation antihistamines were devoid of the central nervous system (CNS) effects such as cognitive and psychomotor impairment. Although these drugs penetrate blood–brain barrier (BBB) to lesser extent, many of them have been found to produce dose-related impairment of CNS functions with interdrug differences present among them.

Aim and Objective: This study is aimed to analyze and compare the effects of different antihistamines (first and second generation) on the CNS using Swiss albino mice.

Materials and Methods: Twenty-four Swiss albino mice of either sex weighing around 25 - 30 g were randomly divided into six groups with six in each group. Antihistamines such as chlorpheniramine maleate (CPM), ebastine, and fexofenadine were administered to respective groups through oral route. Their effects on CNS were evaluated using rotarod and actophotometer. The data were analyzed using statistical methods.

Results: CPM produced significant reduction (P < 0.05) in motor coordination and spontaneous locomotor activity. Ebastine does not have any effect on motor coordination but significant reduction (P < 0.05) in spontaneous locomotor activity. Fexofenadine does not have any effect on motor coordination and spontaneous locomotor activity.

Conclusion: We conclude that CPM has significant CNS depressant actions, ebastine has minimal CNS depressant actions, and fexofenadine does not have CNS depressant actions.

Key words: Antihistamines; Central Nervous System; Spontaneous Locomotor Activity; Motor Coordination

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Sugirda P Articles by Henry Daniel Raj T Articles by Divakar R
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

Web Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. https://www.njppp.com/?mno=99249 [Access: March 14, 2024]. doi:10.5455/njppp.2022.12.0310920220002042022

AMA (American Medical Association) Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

Vancouver/ICMJE Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol. (2022), [cited March 14, 2024]; 12(5): 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

Harvard Style

P, S., T, . H. D. R. & R, . D. (2022) Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol, 12 (5), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

Turabian Style

P, Sugirda, Henry Daniel Raj T, and Divakar R. 2022. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

Chicago Style

P, Sugirda, Henry Daniel Raj T, and Divakar R. "Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

MLA (The Modern Language Association) Style

P, Sugirda, Henry Daniel Raj T, and Divakar R. "Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 12.5 (2022), 657-661. Print. doi:10.5455/njppp.2022.12.0310920220002042022

APA (American Psychological Association) Style

P, S., T, . H. D. R. & R, . D. (2022) Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272