Polypharmacy and potential drug-drug interactions among geriatric patients

Bhavisha N Vegada; Amit M Shah; Deep Shah; Karishma Mogal; Hirva Santoki; Renuka Joshi

doi:10.5455/njppp.2020.10.02055202017032020

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Online Publishing Date:
25 / 03 / 2020

Natl J Physiol Pharm Pharmacol. 2020; 10(5): 393-399

doi: 10.5455/njppp.2020.10.02055202017032020

Polypharmacy and potential drug-drug interactions among geriatric patients

Bhavisha N Vegada, Amit M Shah, Deep Shah, Karishma Mogal, Hirva Santoki, Renuka Joshi.

Abstract
Background: Polypharmacy is common and increasing among geriatric patients. Polypharmacy has been strongly associated with drug-drug interactions (DDIs). Polypharmacy and DDIs represent potential health hazards for the elderly.

Aim and Objective: This study aims to analyze the polypharmacy and associated potential DDIs (pDDIs) among geriatric patients.

Materials and Methods: A total of 484 geriatric (age ≥65 years) patients, who have fulfilled the selection criteria, were included in the study. Polypharmacy was assessed from prescriptions. pDDI was assessed using computer-based checks online available on the internet.

Results: A total of 111 patients (22.93%) were prescribed ≥6 drugs simultaneously polypharmacy. Six patients were prescribed ≥10 drugs (hyperpolypharmacy) simultaneously. A total of 191 (39.46%) prescriptions have at least one pDDI 98 (20.24%) prescriptions, 63 (13.02%) prescriptions, and 30 (6.20%) prescriptions have 12 pDDI, 35 pDDI, and ≥6 pDDI, respectively, with total pDDIs were 578. The statistically significant association has been found between the polypharmacy and pDDI (<0.0001).

Conclusion: The study has identified the polypharmacy as highly significant predictor for pDDIs. Rational prescribing along with the use of information technology can be helpful to improve medication safety in high-risk population like geriatric patients.

Key words: Polypharmacy; Potential Drug-drug Interactions; Geriatrics

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How to Cite this Article

Pubmed Style

Vegada BN, Shah AM, Shah D, Mogal K, Santoki H, Joshi R. Polypharmacy and potential drug-drug interactions among geriatric patients. Natl J Physiol Pharm Pharmacol. 2020; 10(5): 393-399. doi:10.5455/njppp.2020.10.02055202017032020

Web Style

Vegada BN, Shah AM, Shah D, Mogal K, Santoki H, Joshi R. Polypharmacy and potential drug-drug interactions among geriatric patients. https://www.njppp.com/?mno=89727 [Access: March 14, 2024]. doi:10.5455/njppp.2020.10.02055202017032020

AMA (American Medical Association) Style

Vegada BN, Shah AM, Shah D, Mogal K, Santoki H, Joshi R. Polypharmacy and potential drug-drug interactions among geriatric patients. Natl J Physiol Pharm Pharmacol. 2020; 10(5): 393-399. doi:10.5455/njppp.2020.10.02055202017032020

Vancouver/ICMJE Style

Vegada BN, Shah AM, Shah D, Mogal K, Santoki H, Joshi R. Polypharmacy and potential drug-drug interactions among geriatric patients. Natl J Physiol Pharm Pharmacol. (2020), [cited March 14, 2024]; 10(5): 393-399. doi:10.5455/njppp.2020.10.02055202017032020

Harvard Style

Vegada, B. N., Shah, . A. M., Shah, . D., Mogal, . K., Santoki, . H. & Joshi, . R. (2020) Polypharmacy and potential drug-drug interactions among geriatric patients. Natl J Physiol Pharm Pharmacol, 10 (5), 393-399. doi:10.5455/njppp.2020.10.02055202017032020

Turabian Style

Vegada, Bhavisha N, Amit M Shah, Deep Shah, Karishma Mogal, Hirva Santoki, and Renuka Joshi. 2020. Polypharmacy and potential drug-drug interactions among geriatric patients. National Journal of Physiology, Pharmacy and Pharmacology, 10 (5), 393-399. doi:10.5455/njppp.2020.10.02055202017032020

Chicago Style

Vegada, Bhavisha N, Amit M Shah, Deep Shah, Karishma Mogal, Hirva Santoki, and Renuka Joshi. "Polypharmacy and potential drug-drug interactions among geriatric patients." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 393-399. doi:10.5455/njppp.2020.10.02055202017032020

MLA (The Modern Language Association) Style

Vegada, Bhavisha N, Amit M Shah, Deep Shah, Karishma Mogal, Hirva Santoki, and Renuka Joshi. "Polypharmacy and potential drug-drug interactions among geriatric patients." National Journal of Physiology, Pharmacy and Pharmacology 10.5 (2020), 393-399. Print. doi:10.5455/njppp.2020.10.02055202017032020

APA (American Psychological Association) Style

Vegada, B. N., Shah, . A. M., Shah, . D., Mogal, . K., Santoki, . H. & Joshi, . R. (2020) Polypharmacy and potential drug-drug interactions among geriatric patients. National Journal of Physiology, Pharmacy and Pharmacology, 10 (5), 393-399. doi:10.5455/njppp.2020.10.02055202017032020

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