Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes  An experimental animal study in albino rats

Reeja R; Ramani P T; Dawnji S R; Rakesh Praveen Raj M R

doi:10.5455/njppp.2021.11.10263202013102020

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26 / 10 / 2020

Natl J Physiol Pharm Pharmacol. 2020; 10(12): 1128-1137

doi: 10.5455/njppp.2021.11.10263202013102020

Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats

Reeja R, Ramani P T, Dawnji S R, Rakesh Praveen Raj M R.

Abstract
Background: This experimental animal study was designed to evaluate the toxicity profile of two frontline chemotherapeutic regimens used in Hodgkins lymphoma doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and cyclophosphamide, vincristine, procarbazine, and prednisone (COPP), which are regimens commonly prescribed. We conducted this experimental animal study using albino rats, incorporating an antioxidant, Vitamin E, to assess if its cytoprotective properties could counter the free radical inducing actions of the two regimens.

Aims and Objectives: The main objectives of our study were to document histologically, the toxic effects of chemotherapeutic agents in ABVD and COPP regimens in the various organ systems in albino rats, and to assess the protective role of the antioxidant, Vitamin E on drug-induced toxicities in albino rats.

Materials and Methods: In this experimental animal study, 30 albino rats weighing 150 g250 g were selected and grouped as control, chemotherapy receiving group, and cytoprotective group receiving ABVD/COPP and Vitamin E. The duration of the study was 4 weeks and hematological and histopathological studies were conducted on the models.

Results: The experimental study revealed hematological and organ toxicities. Cytoprotection by Vitamin E was evident in the liver and stomach specimens on histopathology. Protection appeared minimal against hematological toxicity.

Conclusions: The experimental animal study demonstrated a cytoprotective effect of Vitamin E against chemotherapy induced organ toxicity mainly in the stomach and liver, of the animals studied.

Key words: Cytoprotective; Vitamin E; ABVD; COPP; Albino Rats

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Pubmed Style

R R, T RP, R DS, R RPRM. Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. Natl J Physiol Pharm Pharmacol. 2020; 10(12): 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

Web Style

R R, T RP, R DS, R RPRM. Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. https://www.njppp.com/?mno=4980 [Access: March 16, 2024]. doi:10.5455/njppp.2021.11.10263202013102020

AMA (American Medical Association) Style

R R, T RP, R DS, R RPRM. Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. Natl J Physiol Pharm Pharmacol. 2020; 10(12): 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

Vancouver/ICMJE Style

R R, T RP, R DS, R RPRM. Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. Natl J Physiol Pharm Pharmacol. (2020), [cited March 16, 2024]; 10(12): 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

Harvard Style

R, R., T, . R. P., R, . D. S. & R, . R. P. R. M. (2020) Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. Natl J Physiol Pharm Pharmacol, 10 (12), 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

Turabian Style

R, Reeja, Ramani P T, Dawnji S R, and Rakesh Praveen Raj M R. 2020. Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 10 (12), 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

Chicago Style

R, Reeja, Ramani P T, Dawnji S R, and Rakesh Praveen Raj M R. "Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

MLA (The Modern Language Association) Style

R, Reeja, Ramani P T, Dawnji S R, and Rakesh Praveen Raj M R. "Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 10.12 (2020), 1128-1137. Print. doi:10.5455/njppp.2021.11.10263202013102020

APA (American Psychological Association) Style

R, R., T, . R. P., R, . D. S. & R, . R. P. R. M. (2020) Cytoprotective role of Vitamin E on the toxicity of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) chemotherapeutic regimes An experimental animal study in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 10 (12), 1128-1137. doi:10.5455/njppp.2021.11.10263202013102020

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