E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application

Sri Agung Fitri Kusuma, Soraya Ratnawulan Mita, Agusrini Mutiara.

Abstract
Background: Empirically red Piper betle leaf (Piper crocatum Ruiz and Pav) is used as a natural antiseptic, and it is proved that the ethanol extract of red P. betle leaf ethanol extract provides antimicrobial activity against the airborne pathogen.

Aims and Objectives: To investigate and determine the most effective of the lotion formulated with red P. betle leaf ethanol extract against airborne pathogens.

Materials and Methods: The plant material in this study was red P. betle leaves that obtained from Bogor Indonesia. The preliminary antimicrobial activity of the extracts at various concentrations was conducted to determine the minimum inhibitory concentration (MIC) of the extract against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The MIC test was performed using an agar diffusion method with perforation technique. Then, antimicrobial lotions (F1–F3) were formulated in varied concentrations (5, 7.5 and 10% w/w) of red P. betle leaf extracts using different excipients and kept for 28 days at 8°C, 25°C, and 40°C. The physicochemical and microbiological parameters of the lotion formulated were evaluated using standard procedures.

Results: MIC range for red P. betle leaf extract was found to be 2.5–5% b/v for all bacteria and 1.25–2.5% b/v for C. albicans. A formulation containing these extracts showed a nonsignificant zone of inhibition for 5%, 7.5%, and 10% of which 10% showed maximum zone of inhibition (ranging from 11.23 to 11.83 mm). All of the lotion formulated were stabil for the physicochemical parameters of evaluation.

Conclusion: The F2 lotion formula had good pharmaceutical properties and potential antimicrobial activity.

Key words: Lotion; Antibacterial; Piper crocatum Ruiz and Pav; Extract; Airborne


 
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Pubmed Style

Kusuma SAF, Mita SR, Mutiara A. Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 130-138. doi:10.5455/njppp.2018.8.1042115112017


Web Style

Kusuma SAF, Mita SR, Mutiara A. Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. http://www.njppp.com/?mno=281965 [Access: April 22, 2018]. doi:10.5455/njppp.2018.8.1042115112017


AMA (American Medical Association) Style

Kusuma SAF, Mita SR, Mutiara A. Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 130-138. doi:10.5455/njppp.2018.8.1042115112017



Vancouver/ICMJE Style

Kusuma SAF, Mita SR, Mutiara A. Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. Natl J Physiol Pharm Pharmacol. (2018), [cited April 22, 2018]; 8(1): 130-138. doi:10.5455/njppp.2018.8.1042115112017



Harvard Style

Kusuma, S. A. F., Mita, S. R. & Mutiara, A. (2018) Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. Natl J Physiol Pharm Pharmacol, 8 (1), 130-138. doi:10.5455/njppp.2018.8.1042115112017



Turabian Style

Kusuma, Sri Agung Fitri, Soraya Ratnawulan Mita, and Agusrini Mutiara. 2018. Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 130-138. doi:10.5455/njppp.2018.8.1042115112017



Chicago Style

Kusuma, Sri Agung Fitri, Soraya Ratnawulan Mita, and Agusrini Mutiara. "Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 130-138. doi:10.5455/njppp.2018.8.1042115112017



MLA (The Modern Language Association) Style

Kusuma, Sri Agung Fitri, Soraya Ratnawulan Mita, and Agusrini Mutiara. "Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 130-138. Print. doi:10.5455/njppp.2018.8.1042115112017



APA (American Psychological Association) Style

Kusuma, S. A. F., Mita, S. R. & Mutiara, A. (2018) Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 130-138. doi:10.5455/njppp.2018.8.1042115112017





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