Service by

Home Journal Issues Guide for Authors Editorial Board About Aims & Scope Editorial Contact


Original Research Open Access


Virtual screening of coformers and solubility test for glibenclamide cocrystallization

Arif Budiman, Sandra Megantara, Ayu Apriliani.

Abstract
Background: The therapeutic effectiveness of active pharmaceutical ingredients (API) depends on their solubility. API, which has poorly soluble drugs, can cause low bioavailability. According to the biopharmaceutical classification system (BCS), glibenclamide is classified under BCS Class II drugs), which has low solubility and high permeability. Cocrystallization is one method to enhance the physical properties of drugs, especially the solubility.

Aims and Objectives: In this study, we apply the approach to the solid state to estimate the probability of cocrystal formation using virtual screening, and then, study the solubility and dissolution test of one of the best coformers.

Materials and Methods: We used virtual screening of coformers for glibenclamide by employing the molecular docking method. AutoDock was used for docking, and the type and energy (Ei) of interaction were observed. The work was continued by the cocrystallization process using dry grinding. Solubility and dissolution tests have referred to the Higuchi and Connor methods using the ultraviolet spectrophotometer.

Results: Based on molecular docking, the best of three from coformers were oxalic acid (Ei = −1.6 kcal/mol), benzoic acid (Ei = −2.6 kcal/mol), and ascorbic acid (Ei = −2.1 kcal/mol). The result of the solubility test showed that glibenclamide oxalic acid increases by 81.6% compared to pure glibenclamide at 24 h. The result of the dissolution test showed that glibenclamide oxalic acid has a better curve (77.3% in 60 min) that pures glibenclamide (44.52% in 60 min).

Conclusion: This study indicated that oxalic acid as a coformer can increase the dissolution profile of glibenclamide by the approach cocrystalization method.

Key words: Cocrystal; Molecular Docking; Glibenclamide; Dry Grinding


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Arif Budiman
Articles by Sandra Megantara
Articles by Ayu Apriliani
on Google
on Google Scholar
Article Statistics
 Viewed: 151
Downloaded: 59
Cited: 0


How to Cite this Article
Pubmed Style

Budiman A, Megantara S, Apriliani A. Virtual screening of coformers and solubility test for glibenclamide cocrystallization. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 124-129. doi:10.5455/njppp.2017.7.0833229092017


Web Style

Budiman A, Megantara S, Apriliani A. Virtual screening of coformers and solubility test for glibenclamide cocrystallization. http://www.njppp.com/?mno=276315 [Access: January 22, 2018]. doi:10.5455/njppp.2017.7.0833229092017


AMA (American Medical Association) Style

Budiman A, Megantara S, Apriliani A. Virtual screening of coformers and solubility test for glibenclamide cocrystallization. Natl J Physiol Pharm Pharmacol. 2018; 8(1): 124-129. doi:10.5455/njppp.2017.7.0833229092017



Vancouver/ICMJE Style

Budiman A, Megantara S, Apriliani A. Virtual screening of coformers and solubility test for glibenclamide cocrystallization. Natl J Physiol Pharm Pharmacol. (2018), [cited January 22, 2018]; 8(1): 124-129. doi:10.5455/njppp.2017.7.0833229092017



Harvard Style

Budiman, A., Megantara, S. & Apriliani, A. (2018) Virtual screening of coformers and solubility test for glibenclamide cocrystallization. Natl J Physiol Pharm Pharmacol, 8 (1), 124-129. doi:10.5455/njppp.2017.7.0833229092017



Turabian Style

Budiman, Arif, Sandra Megantara, and Ayu Apriliani. 2018. Virtual screening of coformers and solubility test for glibenclamide cocrystallization. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 124-129. doi:10.5455/njppp.2017.7.0833229092017



Chicago Style

Budiman, Arif, Sandra Megantara, and Ayu Apriliani. "Virtual screening of coformers and solubility test for glibenclamide cocrystallization." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 124-129. doi:10.5455/njppp.2017.7.0833229092017



MLA (The Modern Language Association) Style

Budiman, Arif, Sandra Megantara, and Ayu Apriliani. "Virtual screening of coformers and solubility test for glibenclamide cocrystallization." National Journal of Physiology, Pharmacy and Pharmacology 8.1 (2018), 124-129. Print. doi:10.5455/njppp.2017.7.0833229092017



APA (American Psychological Association) Style

Budiman, A., Megantara, S. & Apriliani, A. (2018) Virtual screening of coformers and solubility test for glibenclamide cocrystallization. National Journal of Physiology, Pharmacy and Pharmacology, 8 (1), 124-129. doi:10.5455/njppp.2017.7.0833229092017



AUTHOR LOGIN

REVIEWER LOGIN

Indexed In

 

National Journal of Physiology, Pharmacy and Pharmacology is Indexed in -

EMBASE

Index Copernicus  (ICV 2016: 109)

Index Medicus for SEAR

CAB abstract/Global Health

CINAHL

Hinari

Google Scholar

ScopeMed

Ulrich’s International Periodical Directory

Indian Science Abstracts

Open J- Gate

Geneva Foundation for Medical Education and Research

NewJour

PSOAR

InformIndia

EBSCO Publishing Electronic Database

Genamics JournalSeek

ProQuest

Index Scholar

SafetyLit

Chemical Abstracts Service (CAS)

Gale's Health Reference Center

Gale Info Trac

Gale Academic Onefile

Ind Medica

Scirus

Scientific Publication Index

Scientific Resources Database

Recent Science Index

Scholarly Journals Index

Directory of Academic Resources

Elite Scientific Journals Archives

Current Index to Scholarly Journals

Digital Journals Database

Academic Papers Database

Contemporary Research Index

Ayush Web Portal

CiteFactor

 

 

 

 

 

 

Journal Membership

World Association of Medical Editors (WAME), Dallas, Texas, USA

 

Journal Listed in

ICMJE- International Committee of Medical Journal Editors

HIFA 2015 – Healthcare Information for All by 2015, Charlbury, Oxfordshire, UK 

 

 


The articles in this Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.