Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Devarshi Dixit; Sanjeev K. Singh; Anil Kumar Tiwari; Maloy B Mandal

doi:10.5455/njppp.2017.7.0518906062017

2024, Vol: 14, Issue: 4

14 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
17 / 06 / 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(10): 1109-1115

doi: 10.5455/njppp.2017.7.0518906062017

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal.

Abstract
Background: Bisphenol A (BPA) is a plastic toxin widely used in manufacturing of plastic containers. It is known to produce a variety of toxic effects on body functions including reproduction, metabolism, and development. Despite the fact that the gastrointestinal tract is chronically exposed to food containing BPA, its effect on the gut motility is poorly understood.

Aims and Objectives: The present study attempted to assess the small and large gut contractility in vitro in male rats fed with BPA-mixed food for 28 days.

Materials and Methods: This study was carried out in 8 adult male albino rats of 150-200 g weight. One group (4 rats) was subjected to daily oral administration of BPA (50 μg/kg/day) for 28 days. Another group of 4 rats was Sham-fed and served as control. With the help of organ bath preparations and computerized data acquisition system, in vitro isometric contraction (spontaneous and agonist-induced) was recorded from small gut (distal ileum) and large gut (mid colon) segments.

Results: Recordings of spontaneous contractions revealed significantly (P < 0.05) decreased contractile tension in small gut and a decrease in both tension and frequency in large gut of the BPA-fed group of rats.

Conclusion: Chronic exposure of BPA depresses spontaneous and agonist-induced contractility of small and large gut of rats.

Key words: Bisphenol A; Contractility; Ileum; Colon; Acetylch‾ Serotonin; Histamine

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Devarshi Dixit Articles by Sanjeev K. Singh Articles by Anil Kumar Tiwari Articles by Maloy B Mandal
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. Effects of chronic ingestion of Bisphenol A on gut contractility in rats. Natl J Physiol Pharm Pharmacol. 2017; 7(10): 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

Web Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. Effects of chronic ingestion of Bisphenol A on gut contractility in rats. https://www.njppp.com/?mno=267900 [Access: March 16, 2024]. doi:10.5455/njppp.2017.7.0518906062017

AMA (American Medical Association) Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. Effects of chronic ingestion of Bisphenol A on gut contractility in rats. Natl J Physiol Pharm Pharmacol. 2017; 7(10): 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

Vancouver/ICMJE Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. Effects of chronic ingestion of Bisphenol A on gut contractility in rats. Natl J Physiol Pharm Pharmacol. (2017), [cited March 16, 2024]; 7(10): 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

Harvard Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal (2017) Effects of chronic ingestion of Bisphenol A on gut contractility in rats. Natl J Physiol Pharm Pharmacol, 7 (10), 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

Turabian Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. 2017. Effects of chronic ingestion of Bisphenol A on gut contractility in rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (10), 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

Chicago Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. "Effects of chronic ingestion of Bisphenol A on gut contractility in rats." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

MLA (The Modern Language Association) Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal. "Effects of chronic ingestion of Bisphenol A on gut contractility in rats." National Journal of Physiology, Pharmacy and Pharmacology 7.10 (2017), 1109-1115. Print. doi:10.5455/njppp.2017.7.0518906062017

APA (American Psychological Association) Style

Devarshi Dixit, Sanjeev K. Singh, Anil Kumar Tiwari, Maloy B Mandal (2017) Effects of chronic ingestion of Bisphenol A on gut contractility in rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (10), 1109-1115. doi:10.5455/njppp.2017.7.0518906062017

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272