E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
16 / 04 / 2017

 


Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany.


Abstract
Background: Several studies documented the non-hematologic clinical therapeutic uses of recombinant human erythropoietin (EPO). On the other hand, hypertension, thromboembolism, and increased oxidative stress were toxic effects related to the increased hematocrit (Hct) with recombinant human EPO treatment. Accordingly, alternate strategies to reduce erythropoietic activity and other potential side effects of EPO will greatly improve its non-hematopoietic clinical applicability.

Aims and Objectives: Our objective was to demonstrate whether curcumin treatment could attenuate the effect of recombinant human EPO on erythropoiesis in EPO-induced polycythemia, and if so, whether this effect is mediated by changing concentrations of iron and its key regulator hormone hepcidin in rats.

Materials and Methods: Totally 24 male albino Sprague-Dawley rats were included in this study. Rats were equally divided into four groups: Control group, curcumin-treated group, EPO-induced polycythemia group, and curcumin + EPO-induced polycythemia group. Blood indices and serum concentrations of iron, ferritin, and hepcidin were measured.

Results: EPO treatment caused significant increase in hemoglobin (Hb), red blood cells, and Hct versus other study groups (P < 0.05). Curcumin treatment significantly decreased Hct in curcumin-treated group versus control and EPO-induced polycythemia groups (P = 0.021 and 0.008, respectively). Serum iron concentrations were significantly decreased in curcumin + EPO-induced polycythemia group versus control group. Serum ferritin concentrations were significantly decreased in all treated groups versus the control group. Serum hepcidin concentrations were significantly decreased in EPO-induced polycythemia group and curcumin + EPO-induced polycythemia group versus control group.

Conclusion: The presented data suggest a potentially attenuating effect of curcumin administration on recombinant human EPO-induced polycythemia. This effect may be mediated by promoting iron deficiency. However, further studies are required to address the safety of this combination treatment and interspecies differences in iron metabolism between rats and human in addition to have better understanding of the role of the hepcidin.

Key words: Curcumin; Erythropoietin; Erythropoiesis; Iron; Ferritin; Hepcidin


 
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How to Cite this Article
Pubmed Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 766-770. doi:10.5455/njppp.2017.7.0306214032017


Web Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. https://www.njppp.com/?mno=260851 [Access: March 14, 2024]. doi:10.5455/njppp.2017.7.0306214032017


AMA (American Medical Association) Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 766-770. doi:10.5455/njppp.2017.7.0306214032017



Vancouver/ICMJE Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(7): 766-770. doi:10.5455/njppp.2017.7.0306214032017



Harvard Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany (2017) Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. Natl J Physiol Pharm Pharmacol, 7 (7), 766-770. doi:10.5455/njppp.2017.7.0306214032017



Turabian Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. 2017. Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 766-770. doi:10.5455/njppp.2017.7.0306214032017



Chicago Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. "Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 766-770. doi:10.5455/njppp.2017.7.0306214032017



MLA (The Modern Language Association) Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany. "Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats." National Journal of Physiology, Pharmacy and Pharmacology 7.7 (2017), 766-770. Print. doi:10.5455/njppp.2017.7.0306214032017



APA (American Psychological Association) Style

Mona A Hussain, Basma B Hassan, Reham E Masoud, Dalia Al Tamany (2017) Curcumin attenuates erythropoiesis in recombinant human erythropoietin-induced polycythemia in rats. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 766-770. doi:10.5455/njppp.2017.7.0306214032017