Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease

Manouchehr Ashrafpour; Sahar Parsaei; Hamid Sepehri

doi:10.5455/njppp.2015.5.2308201563

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Online Publishing Date:
23 / 11 / 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415

doi: 10.5455/njppp.2015.5.2308201563

Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri.

Abstract
Background: Alzheimers disease (AD) is one of the most common neurodegenerative syndromes characterized by a progressive decline in the spatial memory. There are convincing evidences on the neuroprotective effects of flavonoids against AD.

Aims and Objective: To determine the effect of quercetin on the acquisition and retention of spatial memory in a rat model of AD.

Materials and Methods: Twenty-four male Wistar rats were divided into four groups (six in each): group I: control rats receiving intracerebroventricular (ICV) injection of normal saline, group II: rats induced AD by ICV injection of streptozotocin (STZ; 3 mg/kg bilaterally; twice, on days 1 and 3), and groups III and IV: ICV-STZ AD rats treated intraperitoneally (IP) with 40 and 80 mg/kg/day quercetin, respectively, over a period of 12 days. Then, the rats were trained with four trials per day for five consecutive days in the Morris water maze (MWM). On the sixth day, the memory retention was evaluated.

Result: The ICV-STZ AD groups showed a significant impairment in the acquisition and retrieval of spatial memory when compared with the control group (P < 0.001). In the AD groups, the escape latency during the training trials showed a significant decrease (P < 0.001). Meanwhile, during the MWM task, these rats spent more time in the target quadrant in probe trials when compared with the controls.

Conclusion: Quercetin acted as a spatial memory enhancer in ICV-STZinduced AD rats. Hence, this flavonoid can be considered potentially as a promising agent for developing prophylactic and therapeutic neuroprotection. This neuroprotective effect of quercetin may be attributed to its antioxidant and scavenging properties.

Key words: Quercetin; Spatial Memory; Streptozotocin; Alzheimers Disease

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Pubmed Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415. doi:10.5455/njppp.2015.5.2308201563

Web Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. https://www.njppp.com/?mno=199864 [Access: March 15, 2024]. doi:10.5455/njppp.2015.5.2308201563

AMA (American Medical Association) Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 411-415. doi:10.5455/njppp.2015.5.2308201563

Vancouver/ICMJE Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. Natl J Physiol Pharm Pharmacol. (2015), [cited March 15, 2024]; 5(5): 411-415. doi:10.5455/njppp.2015.5.2308201563

Harvard Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri (2015) Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. Natl J Physiol Pharm Pharmacol, 5 (5), 411-415. doi:10.5455/njppp.2015.5.2308201563

Turabian Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. 2015. Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 411-415. doi:10.5455/njppp.2015.5.2308201563

Chicago Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. "Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 411-415. doi:10.5455/njppp.2015.5.2308201563

MLA (The Modern Language Association) Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri. "Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease." National Journal of Physiology, Pharmacy and Pharmacology 5.5 (2015), 411-415. Print. doi:10.5455/njppp.2015.5.2308201563

APA (American Psychological Association) Style

Manouchehr Ashrafpour, Sahar Parsaei, Hamid Sepehri (2015) Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimers disease. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 411-415. doi:10.5455/njppp.2015.5.2308201563

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