Coagulation profile in pathophysiology of sickle cell anemia

Shehin M; Kanhu Charan Purohit; Sunil Kumar Jena; Basila V

doi:10.5455/njppp.2020.10.08220202019082020

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Online Publishing Date:
28 / 08 / 2020

Natl J Physiol Pharm Pharmacol. 2020; 10(12): 1084-1087

doi: 10.5455/njppp.2020.10.08220202019082020

Coagulation profile in pathophysiology of sickle cell anemia

Shehin M, Kanhu Charan Purohit, Sunil Kumar Jena, Basila V.

Abstract
Background: Sickle cell anemia (SCA) is an emerging public health challenge in India as well as globally. The WHO recognized it as a global problem since long time. In Western Odisha, its prevalence varies from 5% to 30%.

Aim and Objective: The objective of this study was to determine the alteration of the coagulation profile in SCA in comparison to healthy control.

Materials and Methods: This study was completed with 60 subjects that included 30 cases and 30 controls. This study was approved by the Institutional Ethical Committee. The hematological parameters such as bleeding time, clotting time, total platelet count, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were tested. The data were analyzed through SPSS 20.

Results: In this study, it was found that patients with SCA have increased clotting time (P = 0.007), PT (P = 0.000), aPTT (P = 0.003), and total platelet count (P = 0.183), but decreased bleeding time (P = 0.000) in comparison to healthy control.

Conclusion: We found a significant increase in clotting time, PT, and aPTT, but decrease in bleeding time in SCA patients in comparison to healthy adults.

Key words: Coagulation profile; Sickle cell anemia; Hypercoagulability

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Pubmed Style

M S, Purohit KC, Jena SK, V B. Coagulation profile in pathophysiology of sickle cell anemia. Natl J Physiol Pharm Pharmacol. 2020; 10(12): 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

Web Style

M S, Purohit KC, Jena SK, V B. Coagulation profile in pathophysiology of sickle cell anemia. https://www.njppp.com/?mno=124876 [Access: March 14, 2024]. doi:10.5455/njppp.2020.10.08220202019082020

AMA (American Medical Association) Style

M S, Purohit KC, Jena SK, V B. Coagulation profile in pathophysiology of sickle cell anemia. Natl J Physiol Pharm Pharmacol. 2020; 10(12): 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

Vancouver/ICMJE Style

M S, Purohit KC, Jena SK, V B. Coagulation profile in pathophysiology of sickle cell anemia. Natl J Physiol Pharm Pharmacol. (2020), [cited March 14, 2024]; 10(12): 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

Harvard Style

M, S., Purohit, . K. C., Jena, . S. K. & V, . B. (2020) Coagulation profile in pathophysiology of sickle cell anemia. Natl J Physiol Pharm Pharmacol, 10 (12), 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

Turabian Style

M, Shehin, Kanhu Charan Purohit, Sunil Kumar Jena, and Basila V. 2020. Coagulation profile in pathophysiology of sickle cell anemia. National Journal of Physiology, Pharmacy and Pharmacology, 10 (12), 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

Chicago Style

M, Shehin, Kanhu Charan Purohit, Sunil Kumar Jena, and Basila V. "Coagulation profile in pathophysiology of sickle cell anemia." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

MLA (The Modern Language Association) Style

M, Shehin, Kanhu Charan Purohit, Sunil Kumar Jena, and Basila V. "Coagulation profile in pathophysiology of sickle cell anemia." National Journal of Physiology, Pharmacy and Pharmacology 10.12 (2020), 1084-1087. Print. doi:10.5455/njppp.2020.10.08220202019082020

APA (American Psychological Association) Style

M, S., Purohit, . K. C., Jena, . S. K. & V, . B. (2020) Coagulation profile in pathophysiology of sickle cell anemia. National Journal of Physiology, Pharmacy and Pharmacology, 10 (12), 1084-1087. doi:10.5455/njppp.2020.10.08220202019082020

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