E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
05 / 05 / 2020

 


Role of Vitamin D in pre-hypertension and its association with cellular senescence

Himaja Kanumala, Hari Krishna Bandi, Madhusudhana Pulaganti, Venkatachalam Madras.


Abstract
Background: Reports suggest that, in Indian subcontinent, there is 70–100% deficiency of Vitamin D (Vit-D), playing pivotal role in higher risk of development of bone diseases and several noncommunicable disease conditions such as malignancies, metabolic diseases, and cardiovascular disease. Reports on role of Vit-D on cellular senescence in pre-hypertension (pre-HTN) were not available.

Aims and Objectives: The aims of the study were to explore the relationship between Vit-D and cellular senescence measured using the enzyme telomerase in pre-HTN.

Materials and Methods: This investigation was carried out in 41 pre-hypertensives and equal number of age- and gender-matched controls. Cellular senescence was measured by increased levels of telomerase and Vit-D was assessed with using commercially available ELISA assay kits.

Results: Weight and BMI, Systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), rate pressure product ( RPP) and telomerase levels were high and vi-D levels were low in pre-HTN group. Low levels of Vit-D were negatively correlated with telomerase, HR, SBP, and PP.

Conclusion: We concluded that the lower Vit-D levels in pre-HTN could lead to derangements in cardiovascular homeostatic mechanism and enhance the speed of cellular senescence measured by telomerase.

Key words: Cellular Senescence; Pre-hypertension; Telomerase; Vitamin D


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Himaja Kanumala
Articles by Hari Krishna Bandi
Articles by Madhusudhana Pulaganti
Articles by Venkatachalam Madras
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol. 2020; 10(6): 499-503. doi:10.5455/njppp.2020.10.04101202028042020


Web Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. https://www.njppp.com/?mno=101573 [Access: March 14, 2024]. doi:10.5455/njppp.2020.10.04101202028042020


AMA (American Medical Association) Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol. 2020; 10(6): 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Vancouver/ICMJE Style

Kanumala H, Bandi HK, Pulaganti M, Madras V. Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol. (2020), [cited March 14, 2024]; 10(6): 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Harvard Style

Kanumala, H., Bandi, . H. K., Pulaganti, . M. & Madras, . V. (2020) Role of Vitamin D in pre-hypertension and its association with cellular senescence. Natl J Physiol Pharm Pharmacol, 10 (6), 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Turabian Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. 2020. Role of Vitamin D in pre-hypertension and its association with cellular senescence. National Journal of Physiology, Pharmacy and Pharmacology, 10 (6), 499-503. doi:10.5455/njppp.2020.10.04101202028042020



Chicago Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. "Role of Vitamin D in pre-hypertension and its association with cellular senescence." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 499-503. doi:10.5455/njppp.2020.10.04101202028042020



MLA (The Modern Language Association) Style

Kanumala, Himaja, Hari Krishna Bandi, Madhusudhana Pulaganti, and Venkatachalam Madras. "Role of Vitamin D in pre-hypertension and its association with cellular senescence." National Journal of Physiology, Pharmacy and Pharmacology 10.6 (2020), 499-503. Print. doi:10.5455/njppp.2020.10.04101202028042020



APA (American Psychological Association) Style

Kanumala, H., Bandi, . H. K., Pulaganti, . M. & Madras, . V. (2020) Role of Vitamin D in pre-hypertension and its association with cellular senescence. National Journal of Physiology, Pharmacy and Pharmacology, 10 (6), 499-503. doi:10.5455/njppp.2020.10.04101202028042020