E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
13 / 02 / 2020

 


Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels

Meenu Gopalakrishnan, Kamalakshi T V, Geetha P.


Abstract
Background: The coexistence of thyroid dysfunction and diabetes mellitus is increasing in prevalence. Thyroid dysfunction leads to alterations of carbohydrate and lipid metabolism. This study aimed at determining the association between altered thyroid hormone levels, insulin resistance (IR), and serum lipid profile.

Aims and Objectives: The primary objective was to study fetal bovine serum (FBS), serum insulin, IR, and lipid profile in hypothyroid and hyperthyroid patients and to compare them with healthy control subjects. The secondary objective was to correlate IR and lipid profile with serum thyroid-stimulating hormone (TSH).

Materials and Methods: A cross-sectional comparative study including 165 participants of the age group of 18–45 years. Participants were selected after proper exclusion and informed consent. Ethical clearance was obtained from the Institutional Ethics Committee. The following parameters were studied: Serum FBS, serum insulin, IR, total cholesterol, serum high-density lipoprotein, low-density lipoprotein (LDL), and TSH. Statistical analysis was performed using SPSS version 18.

Results: IR has been found elevated in hypothyroid and hyperthyroid subjects. In hypothyroid subjects, a significant elevation in total cholesterol LDL and triglycerides has been found, while in hyperthyroid subjects, no significant alteration in serum lipid profile has been found. IR showed a positive correlation with total cholesterol, LDL, and triglycerides in the hypothyroid group.

Conclusion: The present study showed elevated IR in hypo- and hyper-thyroidism and elevated lipid profile in hypothyroidism.

Key words: Insulin Resistance; Hypothyroidism; Hyperthyroidism; Lipid Profile; Serum Thyroid-Stimulating Hormone; Correlation


 
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How to Cite this Article
Pubmed Style

Gopalakrishnan M, V KT, P G. Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. Natl J Physiol Pharm Pharmacol. 2020; 10(3): 247-252. doi:10.5455/njppp.2020.10.001013202003022020


Web Style

Gopalakrishnan M, V KT, P G. Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. https://www.njppp.com/?mno=82485 [Access: March 14, 2024]. doi:10.5455/njppp.2020.10.001013202003022020


AMA (American Medical Association) Style

Gopalakrishnan M, V KT, P G. Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. Natl J Physiol Pharm Pharmacol. 2020; 10(3): 247-252. doi:10.5455/njppp.2020.10.001013202003022020



Vancouver/ICMJE Style

Gopalakrishnan M, V KT, P G. Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. Natl J Physiol Pharm Pharmacol. (2020), [cited March 14, 2024]; 10(3): 247-252. doi:10.5455/njppp.2020.10.001013202003022020



Harvard Style

Gopalakrishnan, M., V, . K. T. & P, . G. (2020) Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. Natl J Physiol Pharm Pharmacol, 10 (3), 247-252. doi:10.5455/njppp.2020.10.001013202003022020



Turabian Style

Gopalakrishnan, Meenu, Kamalakshi T V, and Geetha P. 2020. Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. National Journal of Physiology, Pharmacy and Pharmacology, 10 (3), 247-252. doi:10.5455/njppp.2020.10.001013202003022020



Chicago Style

Gopalakrishnan, Meenu, Kamalakshi T V, and Geetha P. "Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 247-252. doi:10.5455/njppp.2020.10.001013202003022020



MLA (The Modern Language Association) Style

Gopalakrishnan, Meenu, Kamalakshi T V, and Geetha P. "Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels." National Journal of Physiology, Pharmacy and Pharmacology 10.3 (2020), 247-252. Print. doi:10.5455/njppp.2020.10.001013202003022020



APA (American Psychological Association) Style

Gopalakrishnan, M., V, . K. T. & P, . G. (2020) Insulin resistance and serum lipid profile in hypo- and hyper-thyroidism and their relationship with serum thyroid-stimulating hormone levels. National Journal of Physiology, Pharmacy and Pharmacology, 10 (3), 247-252. doi:10.5455/njppp.2020.10.001013202003022020