E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study

Ellabanthini Hima Bindu, Raghuveer B.

Abstract
Background: Migraine is the most common problem in the world and few angiotensin-converting enzyme (ACE) inhibitors have previously been shown to be effective in migraine prophylaxis.

Aim and Objective: This research aimed to determine the efficacy of enalapril in migraine prophylaxis.

Materials and Methods: A hospital-based observational study of 6 months carried out at outpatient department. A total of 50 patients with migraine attacks of more than 5 in a month were selected and were subjected to complete physical examination, particularly neurological examination. The Headache Impact Test-6 was used to measure the patient’s headaches in terms of mean severity, duration, and frequency within 1 month. A record of each headache attack was maintained by rating on the visual analog scale from 1 to 10 depending on the severity of each attack. Patients were prescribed enalapril 10 mg daily with a dose divided into 5 mg twice daily for 2 months of the study duration.

Results: Headache severity before treatment was 8.33 ± 0.39 and it significantly reduced to 4.65 ± 0.30 in the 1st month and in the 2nd month, it reduced to 4.07 ± 0.50. The mean head ache duration before treatment was 15.94 ± 3.30 and with treatment with enalapril it reduced to 6.79 ± 0.74 in the 1st month and 5.84 ± 0.74 in the 2nd month. The mean headache frequency before the treatment was 14.10 ± 3.00 and by treating with enalapril, it significantly reduced in the 1st month to 9.80 ± 1.79 and 8.76 ± 1.53 in the 2nd month.

Conclusion: Enalapril can be beneficial as it decreases the incidence, intensity and duration of the headaches in migraine prophylaxis. The results of our study support the use of ACE inhibitors in the migraine prophylaxis.

Key words: Migraine; Enalapril; Angiotensin-Converting Enzyme Inhibitors; Angiotensin


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ellabanthini Hima Bindu
Articles by Raghuveer B
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Bindu EH, B R. Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. Natl J Physiol Pharm Pharmacol. 2020; 10(7): 533-536. doi:10.5455/njppp.2020.10.01006202021042020


Web Style

Bindu EH, B R. Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. http://www.njppp.com/?mno=81486 [Access: October 01, 2020]. doi:10.5455/njppp.2020.10.01006202021042020


AMA (American Medical Association) Style

Bindu EH, B R. Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. Natl J Physiol Pharm Pharmacol. 2020; 10(7): 533-536. doi:10.5455/njppp.2020.10.01006202021042020



Vancouver/ICMJE Style

Bindu EH, B R. Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. Natl J Physiol Pharm Pharmacol. (2020), [cited October 01, 2020]; 10(7): 533-536. doi:10.5455/njppp.2020.10.01006202021042020



Harvard Style

Bindu, E. H. & B, . R. (2020) Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. Natl J Physiol Pharm Pharmacol, 10 (7), 533-536. doi:10.5455/njppp.2020.10.01006202021042020



Turabian Style

Bindu, Ellabanthini Hima, and Raghuveer B. 2020. Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. National Journal of Physiology, Pharmacy and Pharmacology, 10 (7), 533-536. doi:10.5455/njppp.2020.10.01006202021042020



Chicago Style

Bindu, Ellabanthini Hima, and Raghuveer B. "Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 533-536. doi:10.5455/njppp.2020.10.01006202021042020



MLA (The Modern Language Association) Style

Bindu, Ellabanthini Hima, and Raghuveer B. "Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study." National Journal of Physiology, Pharmacy and Pharmacology 10.7 (2020), 533-536. Print. doi:10.5455/njppp.2020.10.01006202021042020



APA (American Psychological Association) Style

Bindu, E. H. & B, . R. (2020) Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study. National Journal of Physiology, Pharmacy and Pharmacology, 10 (7), 533-536. doi:10.5455/njppp.2020.10.01006202021042020