E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy

Arun Kumar M, Venkatesh D, Savita Ravindra.

Abstract
Background: It is a common experience that elderly population suffer from degenerative joint disease known as osteoarthritis (OA). There are several biochemical markers that are altered in this low-grade inflammation of knee joint as in OA. Low-level laser therapy (LLLT) is known to be safe and effective methods in the management of pain and inflammation in knee OA.

Aim and Objective: This study aims to study the serum biomarkers to assess the inflammatory status in subjects with knee OA undergoing LLLT.

Materials and Methods: The study subjects were in the age group of 45–75 years who had clinically diagnosed knee OA. The LLLT (810 nm, 10 mW) was given to the subjects for a total duration of 3 months with a periodicity of 3 times a week. Serum osteocalcin and prostaglandin E2 (PGE2) assay were done before and after therapy as well as in controls.

Results: Mean PGE2 in the study subjects before the intervention and after laser therapy was 271.20 ± 128.30 pg/ml and 351.21 ± 98.92 pg/ml, respectively (P = 012). Mean osteocalcin (ng/ml) in the study subjects before the intervention and controls was 9.65 ± 7.90 ng/ml and 4.87 ± 3.23 ng/ml, respectively (P = 004).

Conclusion: It can be concluded that LLLT had anti-inflammatory effects in subjects with knee osteoarthritis (KOA) as evident from significant increase in anti-inflammatory markers such as osteocalcin and PGE2.

Key words: Osteocalcin; Prostaglandin E2; Low-level Laser Therapy; Knee Osteoarthritis


 
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How to Cite this Article
Pubmed Style

M AK, D V, Ravindra S. Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. doi:10.5455/njppp.2020.10.12396201920012020


Web Style

M AK, D V, Ravindra S. Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. http://www.njppp.com/?mno=66710 [Access: March 12, 2020]. doi:10.5455/njppp.2020.10.12396201920012020


AMA (American Medical Association) Style

M AK, D V, Ravindra S. Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. doi:10.5455/njppp.2020.10.12396201920012020



Vancouver/ICMJE Style

M AK, D V, Ravindra S. Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. doi:10.5455/njppp.2020.10.12396201920012020



Harvard Style

M, A. K., D, . V. & Ravindra, . S. (2020) Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. doi:10.5455/njppp.2020.10.12396201920012020



Turabian Style

M, Arun Kumar, Venkatesh D, and Savita Ravindra. 2020. Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. doi:10.5455/njppp.2020.10.12396201920012020



Chicago Style

M, Arun Kumar, Venkatesh D, and Savita Ravindra. "Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy." doi:10.5455/njppp.2020.10.12396201920012020



MLA (The Modern Language Association) Style

M, Arun Kumar, Venkatesh D, and Savita Ravindra. "Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy." doi:10.5455/njppp.2020.10.12396201920012020



APA (American Psychological Association) Style

M, A. K., D, . V. & Ravindra, . S. (2020) Assessment of biochemical markers of inflammation in subjects with knee osteoarthritis undergoing low-level laser therapy. doi:10.5455/njppp.2020.10.12396201920012020





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