E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?

Gunjan Upadhyay, Darshan J Dave, Zalak Asodiya.

Abstract
Background: In past 2 years, COVID-19 pandemic has affected the health care system adversely. World statistics showed a huge rise in the incidence of this highly infectious disease. Abnormal and unregulated immune response was found to be the key deciding factor for the outcome of this disease. A lot of studies showed a promising role of corticosteroids as immunosuppressant agents. They reduce morbidity and mortality in patients with moderate-to-severe COVID-19 disease. However, steroid therapy comes with a huge concern in form of their adverse effects, especially on prolonged use. Optimum duration of steroid therapy is not standardized.

Aim and Objectives: The present study was carried out to determine days of oxygen requirement and duration of hospital stay in patients receiving short course steroid vis-à-vis long course steroid therapy.

Materials and Methods: A retrospective observational study was conducted in tertiary care teaching hospital after prior permission of the Institutional Ethics Committee. All patients diagnosed as having moderate COVID-19 illness with age group of 18–80 years with minimum 03 days of 6 mg dexamethasone or other equivalent steroid administration were included in the study. Patients who were living with HIV/AIDS, cancer, hepatic and renal illness, ischemic and other valvular diseases, and chronic pulmonary diseases affecting oxygenation status were excluded from the study. A total of 203 study participants were enrolled during study period (68 in short course while 135 in long course steroid group). Data were enrolled in predesigned structured and validated case record form.

Results: Short course steroid therapy was found more frequent in <60 years of age. Mean and SD of days of oxygen administration were (4.36 vs. 8.88) and (2.15 vs. 3.43) in short course and long course steroid therapy, respectively. Oxygen requirement for ≥7 days was in (10, 7.41%) patients and (45, 66.18%) patients in short course steroid group and long course steroid group, respectively. Mean and standard deviation of duration of hospital stay were (6.64, 2.87) and (11.9, 4.03) in short course and long course steroid group, respectively. Hospital stay for more than 9 days was (20, 14.81%) and (47, 69.12%) in short course and long course steroid group, respectively.

Conclusion: A positive association was found between duration of hospital stay and long course steroid therapy and was statistically significant. Similarly, a positive association between days of oxygen requirement and long course steroid therapy was found and again it was statistically significant. The study findings indicated that short course steroid therapy was found to be more effective in treatment outcome of COVID-19 illness as far as the duration of hospital stay and oxygen administration parameters are concerned.

Key words: Moderate COVID-19 Illness; Duration of Steroid; Oxygen Requirement; Dexamethasone


 
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How to Cite this Article
Pubmed Style

Upadhyay G, Dave DJ, Asodiya Z. Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022


Web Style

Upadhyay G, Dave DJ, Asodiya Z. Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. https://www.njppp.com/?mno=64973 [Access: September 01, 2022]. doi:10.5455/njppp.2022.12.06302202223062022


AMA (American Medical Association) Style

Upadhyay G, Dave DJ, Asodiya Z. Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022



Vancouver/ICMJE Style

Upadhyay G, Dave DJ, Asodiya Z. Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. Natl J Physiol Pharm Pharmacol. (2022), [cited September 01, 2022]; 12(8): 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022



Harvard Style

Upadhyay, G., Dave, . D. J. & Asodiya, . Z. (2022) Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. Natl J Physiol Pharm Pharmacol, 12 (8), 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022



Turabian Style

Upadhyay, Gunjan, Darshan J Dave, and Zalak Asodiya. 2022. Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022



Chicago Style

Upadhyay, Gunjan, Darshan J Dave, and Zalak Asodiya. "Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022



MLA (The Modern Language Association) Style

Upadhyay, Gunjan, Darshan J Dave, and Zalak Asodiya. "Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?." National Journal of Physiology, Pharmacy and Pharmacology 12.8 (2022), 1256-1260. Print. doi:10.5455/njppp.2022.12.06302202223062022



APA (American Psychological Association) Style

Upadhyay, G., Dave, . D. J. & Asodiya, . Z. (2022) Are short course corticosteroids as effective as longer course in determining days of oxygen requirement and hospital stay in patients with moderate COVID-19 disease?. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1256-1260. doi:10.5455/njppp.2022.12.06302202223062022