Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats

Bhagyalakshmi Dundaiah; Sowbhagya Ramachandregowda; Santosh Anand; Anupama Sindhaghatta Kariyappa; Mamatha Madhugiri Gopinath; Ravikiran Tekupalli

doi:10.5455/njppp.2019.9.0724105072019

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Online Publishing Date:
20 / 07 / 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(10): 955-959

doi: 10.5455/njppp.2019.9.0724105072019

Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats

Bhagyalakshmi Dundaiah, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, Ravikiran Tekupalli.

Abstract
Background: The progressive decline in learning and memory is an inevitable effect of aging. Numerous experimental evidences suggest that diet and physical exercise prevent cognitive deficits with age.

Aims and Objectives: The aim of this study was designed to explore the influence of dietary supplementation of Hemidesmus indicus (HI) extract and swimming exercise on cognitive ability and brain-derived neurotrophic factor (BDNF) expression in rats.

Materials and Methods: Male Wistar rats received oral supplementation of HI extract (50 and 100 mg/kg BW) and swim trained for 84 days, 30 min/day, 6 days/week. The rats were subjected to behavioral studies by T-maze followed by western blotting for BDNF expression.

Results: The synergistic intervention was found to be more effective in improving cognition in terms of acquisition and retention. Training and supplementation of 100 mg/kg BW HI extract enhanced BDNF expression in the different regions of the brain, cerebral cortex, hippocampus, and cerebellum regions of the brain.

Conclusion: Our findings suggest that both interventions improve cognitive ability and promote neurogenesis and can be used as a therapeutic strategy in preventing age-associated neurological disorders.

Key words: Hemidesmus indicus; Dietary Supplementation; Swimming Exercise; Cognition; Brain-derived Neurotrophic Factor

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Pubmed Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 955-959. doi:10.5455/njppp.2019.9.0724105072019

Web Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. https://www.njppp.com/?mno=55133 [Access: March 14, 2024]. doi:10.5455/njppp.2019.9.0724105072019

AMA (American Medical Association) Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 955-959. doi:10.5455/njppp.2019.9.0724105072019

Vancouver/ICMJE Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol. (2019), [cited March 14, 2024]; 9(10): 955-959. doi:10.5455/njppp.2019.9.0724105072019

Harvard Style

Dundaiah, B., Ramachandregowda, . S., Anand, . S., Kariyappa, . A. S., Gopinath, . M. M. & Tekupalli, . R. (2019) Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol, 9 (10), 955-959. doi:10.5455/njppp.2019.9.0724105072019

Turabian Style

Dundaiah, Bhagyalakshmi, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, and Ravikiran Tekupalli. 2019. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 955-959. doi:10.5455/njppp.2019.9.0724105072019

Chicago Style

Dundaiah, Bhagyalakshmi, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, and Ravikiran Tekupalli. "Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 955-959. doi:10.5455/njppp.2019.9.0724105072019

MLA (The Modern Language Association) Style

Dundaiah, Bhagyalakshmi, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, and Ravikiran Tekupalli. "Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats." National Journal of Physiology, Pharmacy and Pharmacology 9.10 (2019), 955-959. Print. doi:10.5455/njppp.2019.9.0724105072019

APA (American Psychological Association) Style

Dundaiah, B., Ramachandregowda, . S., Anand, . S., Kariyappa, . A. S., Gopinath, . M. M. & Tekupalli, . R. (2019) Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 955-959. doi:10.5455/njppp.2019.9.0724105072019

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