E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats

Bhagyalakshmi Dundaiah, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, Ravikiran Tekupalli.

Abstract
Background: The progressive decline in learning and memory is an inevitable effect of aging. Numerous experimental evidences suggest that diet and physical exercise prevent cognitive deficits with age.

Aims and Objectives: The aim of this study was designed to explore the influence of dietary supplementation of Hemidesmus indicus (HI) extract and swimming exercise on cognitive ability and brain-derived neurotrophic factor (BDNF) expression in rats.

Materials and Methods: Male Wistar rats received oral supplementation of HI extract (50 and 100 mg/kg BW) and swim trained for 84 days, 30 min/day, 6 days/week. The rats were subjected to behavioral studies by T-maze followed by western blotting for BDNF expression.

Results: The synergistic intervention was found to be more effective in improving cognition in terms of acquisition and retention. Training and supplementation of 100 mg/kg BW HI extract enhanced BDNF expression in the different regions of the brain, cerebral cortex, hippocampus, and cerebellum regions of the brain.

Conclusion: Our findings suggest that both interventions improve cognitive ability and promote neurogenesis and can be used as a therapeutic strategy in preventing age-associated neurological disorders.

Key words: Hemidesmus indicus; Dietary Supplementation; Swimming Exercise; Cognition; Brain-derived Neurotrophic Factor


 
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How to Cite this Article
Pubmed Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 955-959. doi:10.5455/njppp.2019.9.0724105072019


Web Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. http://www.njppp.com/?mno=55133 [Access: February 16, 2020]. doi:10.5455/njppp.2019.9.0724105072019


AMA (American Medical Association) Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 955-959. doi:10.5455/njppp.2019.9.0724105072019



Vancouver/ICMJE Style

Dundaiah B, Ramachandregowda S, Anand S, Kariyappa AS, Gopinath MM, Tekupalli R. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol. (2019), [cited February 16, 2020]; 9(10): 955-959. doi:10.5455/njppp.2019.9.0724105072019



Harvard Style

Dundaiah, B., Ramachandregowda, . S., Anand, . S., Kariyappa, . A. S., Gopinath, . M. M. & Tekupalli, . R. (2019) Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. Natl J Physiol Pharm Pharmacol, 9 (10), 955-959. doi:10.5455/njppp.2019.9.0724105072019



Turabian Style

Dundaiah, Bhagyalakshmi, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, and Ravikiran Tekupalli. 2019. Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 955-959. doi:10.5455/njppp.2019.9.0724105072019



Chicago Style

Dundaiah, Bhagyalakshmi, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, and Ravikiran Tekupalli. "Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 955-959. doi:10.5455/njppp.2019.9.0724105072019



MLA (The Modern Language Association) Style

Dundaiah, Bhagyalakshmi, Sowbhagya Ramachandregowda, Santosh Anand, Anupama Sindhaghatta Kariyappa, Mamatha Madhugiri Gopinath, and Ravikiran Tekupalli. "Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats." National Journal of Physiology, Pharmacy and Pharmacology 9.10 (2019), 955-959. Print. doi:10.5455/njppp.2019.9.0724105072019



APA (American Psychological Association) Style

Dundaiah, B., Ramachandregowda, . S., Anand, . S., Kariyappa, . A. S., Gopinath, . M. M. & Tekupalli, . R. (2019) Swimming exercise and dietary supplementation of Hemidesmus indicus modulates cognitive decline by enhancing brain-derived neurotrophic factor expression in rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 955-959. doi:10.5455/njppp.2019.9.0724105072019





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