E-ISSN 2231-3206 | ISSN 2320-4672
 

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Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress

Yuvaranjani Gali, Siva Kumar Tekuri, Neeraja Pabbaraju.

Abstract
Background: Ammonia is an important source of nitrogen metabolism and it is necessary for the synthesis of protein and amino acids. An excessive level of ammonia leads to disturbing the physiological functions of the body, causes to increase the free radical levels in tissues and body fluids, its reveal that damage of tissue by reactive oxygen species (ROS) changes of acid-base lances in the body fluidís causesí physiological disturbance and damage of organs.

Aims and Objectives: The present study was conducted to assess the mitigating role of zinc on ammonium sulfate (AS)-induced biochemical alterations (lipid peroxidation [LPO] and antioxidants) in rat liver and muscle.

Materials and Methods: Rats were divided into four groups (six animals in each group). Group I (GI) served as control and rats provided with normal diet and water, Group II (AS) rats treated intraperitoneal (i.p) with 18.3 mg/kg b.w of AS, Group III (zinc chloride [Zc]) rats administered with Zc (4 mg/kg b.w i.p), and Group IV (AS + Zc) treated with both of AS (18.3 mg/kg bwi.p) plus Zc (4 mg/kg b.w i.p) Zc given after 1 h dosage of AS.

Results: In the present investigation, AS-treated animals showed a significant increase in the levels of LPO and declined levels of selected antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) levels in the liver and muscle of rats. On the other hand, only zinc-treated rats (Zc) showed no significant variations in LPO and antioxidants in the liver and muscle. However, in AS + Zc treated animals, elevated levels of LPO and decreased SOD, CAT, GPx, and GR antioxidant levels were reversed to normal when compared with AS-treated rats.

Conclusion: Accordingly, these findings suggest that zinc supplementation significantly inhibits the oxidative stress in hepatic cells and muscle cells in AS toxicity.

Key words: Ammonium sulfate; Zinc chloride; Lipid peroxidation; Antioxidants; Liver; Muscle


 
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How to Cite this Article
Pubmed Style

Gali Y, Tekuri SK, Pabbaraju N. Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 695-699. doi:10.5455/njppp.2019.9.0416013052019


Web Style

Gali Y, Tekuri SK, Pabbaraju N. Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. http://www.njppp.com/?mno=45799 [Access: February 17, 2020]. doi:10.5455/njppp.2019.9.0416013052019


AMA (American Medical Association) Style

Gali Y, Tekuri SK, Pabbaraju N. Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 695-699. doi:10.5455/njppp.2019.9.0416013052019



Vancouver/ICMJE Style

Gali Y, Tekuri SK, Pabbaraju N. Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. Natl J Physiol Pharm Pharmacol. (2019), [cited February 17, 2020]; 9(7): 695-699. doi:10.5455/njppp.2019.9.0416013052019



Harvard Style

Gali, Y., Tekuri, . S. K. & Pabbaraju, . N. (2019) Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. Natl J Physiol Pharm Pharmacol, 9 (7), 695-699. doi:10.5455/njppp.2019.9.0416013052019



Turabian Style

Gali, Yuvaranjani, Siva Kumar Tekuri, and Neeraja Pabbaraju. 2019. Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 695-699. doi:10.5455/njppp.2019.9.0416013052019



Chicago Style

Gali, Yuvaranjani, Siva Kumar Tekuri, and Neeraja Pabbaraju. "Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 695-699. doi:10.5455/njppp.2019.9.0416013052019



MLA (The Modern Language Association) Style

Gali, Yuvaranjani, Siva Kumar Tekuri, and Neeraja Pabbaraju. "Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress." National Journal of Physiology, Pharmacy and Pharmacology 9.7 (2019), 695-699. Print. doi:10.5455/njppp.2019.9.0416013052019



APA (American Psychological Association) Style

Gali, Y., Tekuri, . S. K. & Pabbaraju, . N. (2019) Role of zinc on lipid peroxidation and antioxidant status in liver and muscle tissues of rats under ammonium sulfate-induced stress. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 695-699. doi:10.5455/njppp.2019.9.0416013052019