E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of the effect of Nishamalaki on cataract in diabetic rats

Pallawi Khatavkar, Jayshree Dawane, Madhura Bhosale, Vijaya Pandit, Pradnya Padalkar.

Abstract
Background: Diabetes mellitus is a metabolic disorder, leading to many complications. Cataract is important complication causing impairment of vision. Many factors play a role in cataract formation in diabetic individuals. Only treatment for cataract is surgery, having limitations. There is a need to explore for inexpensive, non-surgical approaches for prevention of cataract. The present study was planned to evaluate the effect of Nishamalaki (NA) on diabetic cataract.

Aims and Objectives: This study aims to study the prophylactic and therapeutic effect of NA on cataract and its mechanism of action.

Materials and Methods: Diabetes was induced in 42 Wistar rats with low-dose streptozotocin (STZ) followed by high-fat high-fructose diet. NA treatment initiated in six rats immediately after STZ administration (NA prophylactic Group II). Once diabetes was developed rats divided into six groups and received respective treatment for 8 weeks: Group I – diabetic control, Group III – NA therapeutic, Group IV – glimepiride, Group V – chloramphenicol, Group VI – glutamine, and Group VII – epalrestat. Then, estimation of aldose reductase (AR) and antioxidant enzymes in blood and lens was done.

Results: In Group I, cataract was initiated in the 2nd week and progressed to Stage 3 or 4 by the 8th week. No cataract was developed in NA prophylactic and chloramphenicol group. Delayed initiation and progression were seen in NA therapeutic and epalrestat, compared to glimepiride and glutamine group. NA was seen to work by antihyperglycemic, antioxidant, AR inhibition, and probably by CYP 450 inhibition.

Conclusion: NA is useful in the prevention and treatment of cataract in diabetic animals, working through many mechanisms.

Key words: Diabetes Mellitus; Cataract Score; Oxidative Stress; Nishamalaki


 
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Pubmed Style

Khatavkar P, Dawane J, Bhosale M, Pandit V, Padalkar P. Evaluation of the effect of Nishamalaki on cataract in diabetic rats. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 639-646. doi:10.5455/njppp.2019.9.0413227042019


Web Style

Khatavkar P, Dawane J, Bhosale M, Pandit V, Padalkar P. Evaluation of the effect of Nishamalaki on cataract in diabetic rats. http://www.njppp.com/?mno=42258 [Access: October 18, 2019]. doi:10.5455/njppp.2019.9.0413227042019


AMA (American Medical Association) Style

Khatavkar P, Dawane J, Bhosale M, Pandit V, Padalkar P. Evaluation of the effect of Nishamalaki on cataract in diabetic rats. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 639-646. doi:10.5455/njppp.2019.9.0413227042019



Vancouver/ICMJE Style

Khatavkar P, Dawane J, Bhosale M, Pandit V, Padalkar P. Evaluation of the effect of Nishamalaki on cataract in diabetic rats. Natl J Physiol Pharm Pharmacol. (2019), [cited October 18, 2019]; 9(7): 639-646. doi:10.5455/njppp.2019.9.0413227042019



Harvard Style

Khatavkar, P., Dawane, . J., Bhosale, . M., Pandit, . V. & Padalkar, . P. (2019) Evaluation of the effect of Nishamalaki on cataract in diabetic rats. Natl J Physiol Pharm Pharmacol, 9 (7), 639-646. doi:10.5455/njppp.2019.9.0413227042019



Turabian Style

Khatavkar, Pallawi, Jayshree Dawane, Madhura Bhosale, Vijaya Pandit, and Pradnya Padalkar. 2019. Evaluation of the effect of Nishamalaki on cataract in diabetic rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 639-646. doi:10.5455/njppp.2019.9.0413227042019



Chicago Style

Khatavkar, Pallawi, Jayshree Dawane, Madhura Bhosale, Vijaya Pandit, and Pradnya Padalkar. "Evaluation of the effect of Nishamalaki on cataract in diabetic rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 639-646. doi:10.5455/njppp.2019.9.0413227042019



MLA (The Modern Language Association) Style

Khatavkar, Pallawi, Jayshree Dawane, Madhura Bhosale, Vijaya Pandit, and Pradnya Padalkar. "Evaluation of the effect of Nishamalaki on cataract in diabetic rats." National Journal of Physiology, Pharmacy and Pharmacology 9.7 (2019), 639-646. Print. doi:10.5455/njppp.2019.9.0413227042019



APA (American Psychological Association) Style

Khatavkar, P., Dawane, . J., Bhosale, . M., Pandit, . V. & Padalkar, . P. (2019) Evaluation of the effect of Nishamalaki on cataract in diabetic rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 639-646. doi:10.5455/njppp.2019.9.0413227042019





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